Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral sphincter in non-injured and chronically transected urethane-anesthetized rats.
Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral sphincter in non-injured and chronically transected urethane-anesthetized rats.
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DOI：
10.1038/s41598-023-39388-9
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发表时间：
2023-07-28
影响因子：
4.6
通讯作者：
Hubscher, Charles H.
中科院分区：
文献类型：
--
作者：
Medina-Aguinaga, Daniel;Hoey, Robert F.;Wilkins, Natasha L.;Ugiliweneza, Beatrice;Fell, Jason;Harkema, Susan J.;Hubscher, Charles H.
最近的临床前和临床脊髓硬膜外刺激（scES）实验，专门针对胸腰椎和腰骶回路介导下尿路（LUT）功能，已显示出改善存储，逼尿肌压力和排空。由于大鼠中存在与排尿期间的外尿道括约肌（EUS）功能相关的腰椎协调中心，因此在当前研究中使用scES靶向腰中脊髓（特别是L3），以确定在乌拉坦麻醉下使用完整和慢性完全脊髓损伤的雌性大鼠是否可以调节EUS，从而调节排尿模式。L3 scES在选定的频率和强度的刺激产生了减少空隙体积和EUS突发持续时间在完整的大鼠。慢性横断后，确定了三个不同的LUT功能障碍亚组，对L3 scES的反应促进了不同的膀胱测压结果，包括EUS爆发的变化。目前的研究结果表明，在L3水平的scES可以产生膀胱和EUS在完整和SCI大鼠的功能性神经调节，以提高在各种临床情况下的排尿。
Recent pre-clinical and clinical spinal cord epidural stimulation (scES) experiments specifically targeting the thoracolumbar and lumbosacral circuitries mediating lower urinary tract (LUT) function have shown improvements in storage, detrusor pressure, and emptying. With the existence of a lumbar spinal coordinating center in rats that is involved with external urethral sphincter (EUS) functionality during micturition, the mid-lumbar spinal cord (specifically L3) was targeted in the current study with scES to determine if the EUS and thus the void pattern could be modulated, using both intact and chronic complete spinal cord injured female rats under urethane anesthesia. L3 scES at select frequencies and intensities of stimulation produced a reduction in void volumes and EUS burst duration in intact rats. After chronic transection, three different subgroups of LUT dysfunction were identified and the response to L3 scES promoted different cystometry outcomes, including changes in EUS bursting. The current findings suggest that scES at the L3 level can generate functional neuromodulation of both the urinary bladder and the EUS in intact and SCI rats to enhance voiding in a variety of clinical scenarios.
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影响因子：
2
作者：
Wada N;Shimizu T;Takai S;Shimizu N;Kanai AJ;Tyagi P;Kakizaki H;Yoshimura N
通讯作者：
Yoshimura N
DOI：
10.1038/sc.1982.65
发表时间：
1982-01-01
期刊：
PARAPLEGIA
影响因子：
--
作者：
BRINDLEY, GS;POLKEY, CE;RUSHTON, DN
通讯作者：
RUSHTON, DN
影响因子：
2.6
作者：
Karnup, S., V;De Groat, W. C.
通讯作者：
De Groat, W. C.
影响因子：
3.3
作者：
Karnup, Sergei, V;de Groat, William C.
通讯作者：
de Groat, William C.
影响因子：
5.3
作者：
Capogrosso, Marco;Wenger, Nikolaus;Micera, Silvestro
通讯作者：
Micera, Silvestro