Elevated circulating vaspin levels were decreased by rosiglitazone therapy in T2DM patients with poor glycemic control on metformin alone.
Elevated circulating vaspin levels were decreased by rosiglitazone therapy in T2DM patients with poor glycemic control on metformin alone.
复制标题
对于单用二甲双胍血糖控制不佳的 T2DM 患者，罗格列酮治疗可降低升高的循环 vaspin 水平。
作者：
Vaspin被认为是一种新型的脂肪因子，具有潜在的胰岛素增敏特性。本研究的目的是观察罗格列酮对单用二甲双胍控制不佳的2型糖尿病患者血浆血管紧张素转换酶的影响。本研究共纳入105例患者，包括37例糖耐量正常(NGT)患者、37例糖调节受损(IGR)患者和31例单纯二甲双胍治疗后血糖控制不良的T2 DM患者。血糖控制不良的T2 DM患者空腹血浆vaspin水平明显高于糖耐量减低组和糖耐量减低组(1.19±0.74vs.0.46±0.26和0.54±0.28μg/L，P<0.05)。IGR组与NGT组之间差异无统计学意义。T2 DM患者经罗格列酮治疗12周后，空腹血浆vaspin水平显著降低(1.19±0.74vs.0.91±0.54vs.0.91±0.54vs.0.91±0.54μg/L，P<；0.05)，同时胰岛素敏感性和血糖控制明显改善。血浆vaspin水平与空腹胰岛素和胰岛素抵抗稳态模型评估(HOMA-IR)呈正相关。结论：血糖控制不良的T2 DM患者血浆vaspin水平较高。罗格列酮治疗通过调节血糖和胰岛素敏感性降低血浆vaspin水平。
Vaspin has been regarded as a novel adipokine with potential insulin sensitizing properties. The aim of the present study is to investigate the effects of rosiglitazone therapy on plasma vaspin in type 2 diabetes patients (T2DM) inadequately controlled on metformin alone. A total of 105 subjects, including 37 subjects with normal glucose tolerance (NGT), 37 subjects with impaired glucose regulating (IGR), and 31 T2DM patients with poor glycemic control on metformin alone were enrolled in this study. Fasting plasma vaspin levels were higher in T2DM patients with poor glycemic control than that in IGR and NGT groups (1.19±0.74 vs. 0.46±0.26 and 0.54±0.28μg/L, P<0.05). There was no difference between IGR and NGT groups. In T2DM patients, fasting plasma vaspin concentrations were significantly decreased after rosiglizatone therapy for 12weeks (1.19±0.74 vs. 0.91±0.54μg/L, P<0.05), accompanied with significant amelioration of insulin sensitivity and glucose control. Plasma vaspin levels were positively associated with the fasting insulin and the homeostasis model assessment of IR (HOMA-IR). In conclusion, plasma vaspin level is higher in T2DM patients with poor glycemic control. And rosiglitazone therapy decreased plasma vaspin levels through glucose and insulin sensitivity regulation.
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