Hypertension two years after renal transplantation: causes and consequences
Hypertension two years after renal transplantation: causes and consequences
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肾移植后两年高血压：原因和后果
DOI：
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发表时间：
1995
影响因子：
3.1
通讯作者：
E. Pettersson
中科院分区：
文献类型：
--
作者：
C. Warholm;H. Wilczek;E. Pettersson
回顾性分析肾移植术后2年高血压的发生率及可能的病因。一组93例患者治疗环孢素（CyA），硫唑嘌呤（Aza），和/或泼尼松龙（Pred）进行了比较，一组31例患者治疗Aza和Pred。有更多的高血压患者在CyA组（73%）比Aza组（58%）。移植前高血压易导致移植后高血压。移植后，高血压在多囊肾（46%）、慢性肾小球肾炎（67%）和糖尿病（71%）患者中最常见。免疫抑制药物累积（CyA/Pred）对高血压的发生无影响。高血压患者的移植肾功能明显低于正常血压患者（血清肌酐水平229 μmol/l比162 μmol/l，P<0.01）。高血压组移植肾10年存活率明显低于正常血压组（42% vs 65%，P<0.05）。10年生存率分别为59%和79%（P=NS）。该研究进一步证实了高血压对移植物和患者存活率有负面影响的常见发现。
The incidence of hypertension 2 years after renal transplantation and the possible causes of hypertension were studied retrospectively. A group of 93 patients treated with cyclosporin (CyA), azathioprine (Aza), and/or prednisolone (Pred) were compared to a group of 31 patients treated with Aza and Pred. There were more patients with hypertension in the CyA group (73%) than in the Aza group (58%). Hypertension before transplantation predisposed to hypertension after transplantation. After transplantation, hypertension was most common among patients with polycystic kidney disease (46%), chronic glomerulonephritis (67%), and diabetes (71%). The accumulated immunosuppressive medication (CyA/Pred) did not affect the occurrence of hypertension. Hypertensive patients had significantly poorer graft function than did normotensive patients (serum creatinine level 229 μmol/l vs 162 μmol/l, P<0.01). The 10-year graft survival was markedly impaired in the group with hypertension (42% vs 65% for normotensives, P<0.05). The 10-year patient survival was 59% vs 79% (P=NS). The study further confirms the frequent finding that hypertension has a negative effect on graft and patient survival rates.
肾移植后高血压：环孢素增加了诊断和治疗的考虑。
DOI：
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发表时间：
1989
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
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作者：
Curtis,JJ
通讯作者：
Curtis,JJ
具有一年功能的肾移植受者的长期前景。
影响因子：
6.2
作者：
Fischel,RJ;Payne,WD;Gillingham,KJ;Dunn,DL;Sutherland,DE;Matas,AJ;Najarian,JS
通讯作者：
Najarian,JS