Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
复制标题
DOI：
10.1038/ng.448
复制
发表时间：
2009-10
期刊：
影响因子：
30.8
通讯作者：
Stefansson, Kari
中科院分区：
文献类型：
--
作者：
Gudmundsson, Julius;Sulem, Patrick;Gudbjartsson, Daniel F.;Blondal, Thorarinn;Gylfason, Arnaldur;Agnarsson, Bjarni A.;Benediktsdottir, Kristrun R.;Magnusdottir, Droplaug N.;Orlygsdottir, Gudbjorg;Jakobsdottir, Margret;Stacey, Simon N.;Sigurdsson, Asgeir;Wahlfors, Tiina;Tammela, Teuvo;Breyer, Joan P.;McReynolds, Kate M.;Bradley, Kevin M.;Saez, Berta;Godino, Javier;Navarrete, Sebastian;Fuertes, Fernando;Murillo, Laura;Polo, Eduardo;Aben, Katja K.;van Oort, Inge M.;Suarez, Brian K.;Helfand, Brian T.;Kan, Donghui;Zanon, Carlo;Frigge, Michael L.;Kristjansson, Kristleifur;Gulcher, Jeffrey R.;Einarsson, Gudmundur V.;Jonsson, Eirikur;Catalona, William J.;Mayordomo, Jose I.;Kiemeney, Lambertus A.;Smith, Jeffrey R.;Schleutker, Johanna;Barkardottir, Rosa B.;Kong, Augustine;Thorsteinsdottir, Unnur;Rafnar, Thorunn;Stefansson, Kari
我们报告了一项关于前列腺癌的全基因组关联随访研究。我们在欧洲人群中确定了与该疾病相关的四种变异：3q21.3 上的 rs10934853-A（OR = 1.12，P = 2.9×10−10），8q24.21 上的两个中度相关（r2 = 0.07）变异； 19q13.2 上的 rs16902094-G（OR = 1.21，P = 6.2×10−15）和 rs445114-T（OR = 1.14，P = 4.7×10−10）和 rs8102476-C（OR = 1.12，P = 1.6×10−11）。我们还用 SNP rs11228565-A 细化了 11q13 上先前的关联信号（OR = 1.23，P = 6.7 × 10−12）。在多变量分析中，使用冰岛人群中分型的 22 种前列腺癌风险变异，我们估计属于风险分布前 1.3% 的携带者患该疾病的风险比人群平均风险估计高 2.5 倍以上。
We report a genome-wide association follow up study on prostate cancer. We identify four variants associated with the disease in European populations: rs10934853-A (OR = 1.12, P = 2.9×10−10) on 3q21.3, two moderately correlated (r2 = 0.07) variants on 8q24.21; rs16902094-G (OR = 1.21, P = 6.2×10−15) and rs445114-T (OR = 1.14, P = 4.7×10−10) and rs8102476-C (OR = 1.12, P = 1.6×10−11) on 19q13.2. We also refine a previous association signal on 11q13 with the SNP rs11228565-A (OR =1.23, P = 6.7 × 10−12). In a multi-variant analysis, using 22 prostate cancer risk variants typed in the Icelandic population, we estimate that carriers belonging to the top 1.3% of the risk distribution have a risk of developing the disease that is more than 2.5 times greater than the population average risk estimates.
登录
查看更多内容
影响因子：
30.8
作者：
Kiemeney LA;Thorlacius S;Sulem P;Geller F;Aben KK;Stacey SN;Gudmundsson J;Jakobsdottir M;Bergthorsson JT;Sigurdsson A;Blondal T;Witjes JA;Vermeulen SH;Hulsbergen-van de Kaa CA;Swinkels DW;Ploeg M;Cornel EB;Vergunst H;Thorgeirsson TE;Gudbjartsson D;Gudjonsson SA;Thorleifsson G;Kristinsson KT;Mouy M;Snorradottir S;Placidi D;Campagna M;Arici C;Koppova K;Gurzau E;Rudnai P;Kellen E;Polidoro S;Guarrera S;Sacerdote C;Sanchez M;Saez B;Valdivia G;Ryk C;de Verdier P;Lindblom A;Golka K;Bishop DT;Knowles MA;Nikulasson S;Petursdottir V;Jonsson E;Geirsson G;Kristjansson B;Mayordomo JI;Steineck G;Porru S;Buntinx F;Zeegers MP;Fletcher T;Kumar R;Matullo G;Vineis P;Kiltie AE;Gulcher JR;Thorsteinsdottir U;Kong A;Rafnar T;Stefansson K
通讯作者：
Stefansson K
影响因子：
2.1
作者：
Nicolae, Dan L.
通讯作者：
Nicolae, Dan L.
影响因子：
30.8
作者：
Haiman, Christopher A.;Patterson, Nick;Reich, David
通讯作者：
Reich, David
影响因子：
10.3
作者：
Ghoussaini, Maya;Song, Honglin;Dunning, Alison M.
通讯作者：
Dunning, Alison M.
影响因子：
9.8
作者：
Zaitlen, Noah;Kang, Hyun Min;Halperin, Eran
通讯作者：
Halperin, Eran