Chimpanzee genomic diversity reveals ancient admixture with bonobos.
Chimpanzee genomic diversity reveals ancient admixture with bonobos.
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DOI：
10.1126/science.aag2602
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发表时间：
2016-10-28
期刊：
影响因子：
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通讯作者：
Marques-Bonet T
中科院分区：
文献类型：
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作者：
de Manuel M;Kuhlwilm M;Frandsen P;Sousa VC;Desai T;Prado-Martinez J;Hernandez-Rodriguez J;Dupanloup I;Lao O;Hallast P;Schmidt JM;Heredia-Genestar JM;Benazzo A;Barbujani G;Peter BM;Kuderna LF;Casals F;Angedakin S;Arandjelovic M;Boesch C;Kühl H;Vigilant L;Langergraber K;Novembre J;Gut M;Gut I;Navarro A;Carlsen F;Andrés AM;Siegismund HR;Scally A;Excoffier L;Tyler-Smith C;Castellano S;Xue Y;Hvilsom C;Marques-Bonet T
我们现存的近亲，黑猩猩和矮黑猩猩，有着复杂的人口统计学历史。我们分析了来自非洲10个国家的75只野生出生的黑猩猩和矮黑猩猩的高覆盖率全基因组。我们发现，黑猩猩种群的亚结构使得遗传信息可以很好地预测国家和区域尺度上的地理起源。最引人注目的是，多条证据表明，在20万到55万年前(Kya)之间，基因从矮黑猩猩流向中部和东部黑猩猩的祖先，很可能随后传播到尼日利亚-喀麦隆黑猩猩。加上另一次可能更近的接触(200Kya之后)，矮黑猩猩对中央黑猩猩基因组的贡献不到1%。因此，在原始人进化过程中，混血现象似乎很普遍。
Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We have analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from ten countries in Africa. We find that chimpanzee population sub-structure makes genetic information a good predictor of geographic origin at country and regional scales. Most strikingly, multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200 and 550 thousand years ago (Kya), probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another possibly more recent contact (after 200 Kya), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.
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BONOBO基因组与黑猩猩和人类基因组相比。
影响因子：
64.8
作者：
Pruefer, Kay;Munch, Kasper;Hellmann, Ines;Akagi, Keiko;Miller, Jason R.;Walenz, Brian;Koren, Sergey;Sutton, Granger;Kodira, Chinnappa;Winer, Roger;Knight, James R.;Mullikin, James C.;Meader, Stephen J.;Ponting, Chris P.;Lunter, Gerton;Higashino, Saneyuki;Hobolth, Asger;Dutheil, Julien;Karakoc, Emre;Alkan, Can;Sajjadian, Saba;Catacchio, Claudia Rita;Ventura, Mario;Marques-Bonet, Tomas;Eichler, Evan E.;Andre, Claudine;Atencia, Rebeca;Mugisha, Lawrence;Junhold, Joerg;Patterson, Nick;Siebauer, Michael;Good, Jeffrey M.;Fischer, Anne;Ptak, Susan E.;Lachmann, Michael;Symer, David E.;Mailund, Thomas;Schierup, Mikkel H.;Andres, Aida M.;Kelso, Janet;Paeaebo, Svante
通讯作者：
Paeaebo, Svante
影响因子：
64.8
作者：
通讯作者：
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影响因子：
64.8
作者：
Li, Heng;Durbin, Richard
通讯作者：
Durbin, Richard
影响因子：
1.7
作者：
Hvilsom, Christina;Carlsen, Frands;Siegismund, Hans R.
通讯作者：
Siegismund, Hans R.
来自阿尔泰山脉的尼安德特人的完整基因组序列。
影响因子：
64.8
作者：
通讯作者：
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