The bonobo genome compared with the chimpanzee and human genomes.
The bonobo genome compared with the chimpanzee and human genomes.
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BONOBO基因组与黑猩猩和人类基因组相比。
DOI：
10.1038/nature11128
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发表时间：
2012-06-28
期刊：
影响因子：
64.8
通讯作者：
Paeaebo, Svante
中科院分区：
文献类型：
--
作者：
Pruefer, Kay;Munch, Kasper;Hellmann, Ines;Akagi, Keiko;Miller, Jason R.;Walenz, Brian;Koren, Sergey;Sutton, Granger;Kodira, Chinnappa;Winer, Roger;Knight, James R.;Mullikin, James C.;Meader, Stephen J.;Ponting, Chris P.;Lunter, Gerton;Higashino, Saneyuki;Hobolth, Asger;Dutheil, Julien;Karakoc, Emre;Alkan, Can;Sajjadian, Saba;Catacchio, Claudia Rita;Ventura, Mario;Marques-Bonet, Tomas;Eichler, Evan E.;Andre, Claudine;Atencia, Rebeca;Mugisha, Lawrence;Junhold, Joerg;Patterson, Nick;Siebauer, Michael;Good, Jeffrey M.;Fischer, Anne;Ptak, Susan E.;Lachmann, Michael;Symer, David E.;Mailund, Thomas;Schierup, Mikkel H.;Andres, Aida M.;Kelso, Janet;Paeaebo, Svante
两种非洲猿是人类现存的近亲：黑猩猩（Pan troglodytes）和倭黑猩猩（Pan paniscus）。虽然倭黑猩猩和黑猩猩在许多方面都很相似，但它们在关键的社会和性行为上却有着惊人的差异，而且在其中一些特征上，它们与人类的相似性要大于彼此之间的相似性。在这里，我们报告倭黑猩猩基因组的测序和组装，以研究其与黑猩猩和人类基因组的进化关系。我们发现，超过3%的人类基因组与倭黑猩猩或黑猩猩基因组的关系比它们之间的关系更密切。这些区域使这两种猿类祖先的各个方面得以重建。此外，许多基因重叠的区域最终可能有助于我们理解人类与两种猿类中的一种共有而另一种被排除在外的表型的遗传基础。
Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.
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影响因子：
4.5
作者：
Hobolth A;Christensen OF;Mailund T;Schierup MH
通讯作者：
Schierup MH
在人类基因组中近期阳性选择的地图。
影响因子：
9.8
作者：
Voight BF;Kudaravalli S;Wen X;Pritchard JK
通讯作者：
Pritchard JK
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
3.7
作者：
Fischer, Anne;Pruefer, Kay;Paeaebo, Svante
通讯作者：
Paeaebo, Svante
影响因子：
64.8
作者：
Locke, Devin P.;Hillier, LaDeana W.;Warren, Wesley C.;Worley, Kim C.;Nazareth, Lynne V.;Muzny, Donna M.;Yang, Shiaw-Pyng;Wang, Zhengyuan;Chinwalla, Asif T.;Minx, Pat;Mitreva, Makedonka;Cook, Lisa;Delehaunty, Kim D.;Fronick, Catrina;Schmidt, Heather;Fulton, Lucinda A.;Fulton, Robert S.;Nelson, Joanne O.;Magrini, Vincent;Pohl, Craig;Graves, Tina A.;Markovic, Chris;Cree, Andy;Dinh, Huyen H.;Hume, Jennifer;Kovar, Christie L.;Fowler, Gerald R.;Lunter, Gerton;Meader, Stephen;Heger, Andreas;Ponting, Chris P.;Marques-Bonet, Tomas;Alkan, Can;Chen, Lin;Cheng, Ze;Kidd, Jeffrey M.;Eichler, Evan E.;White, Simon;Searle, Stephen;Vilella, Albert J.;Chen, Yuan;Flicek, Paul;Ma, Jian;Raney, Brian;Suh, Bernard;Burhans, Richard;Herrero, Javier;Haussler, David;Faria, Rui;Fernando, Olga;Darre, Fleur;Farre, Domenec;Gazave, Elodie;Oliva, Meritxell;Navarro, Arcadi;Roberto, Roberta;Capozzi, Oronzo;Archidiacono, Nicoletta;Della Valle, Giuliano;Purgato, Stefania;Rocchi, Mariano;Konkel, Miriam K.;Walker, Jerilyn A.;Ullmer, Brygg;Batzer, Mark A.;Smit, Arian F. A.;Hubley, Robert;Casola, Claudio;Schrider, Daniel R.;Hahn, Matthew W.;Quesada, Victor;Puente, Xose S.;Ordonez, Gonzalo R.;Lopez-Otin, Carlos;Vinar, Tomas;Brejova, Brona;Ratan, Aakrosh;Harris, Robert S.;Miller, Webb;Kosiol, Carolin;Lawson, Heather A.;Taliwal, Vikas;Martins, Andre L.;Siepel, Adam;RoyChoudhury, Arindam;Ma, Xin;Degenhardt, Jeremiah;Bustamante, Carlos D.;Gutenkunst, Ryan N.;Mailund, Thomas;Dutheil, Julien Y.;Hobolth, Asger;Schierup, Mikkel H.;Ryder, Oliver A.;Yoshinaga, Yuko;de Jong, Pieter J.;Weinstock, George M.;Rogers, Jeffrey;Mardis, Elaine R.;Gibbs, Richard A.;Wilson, Richard K.
通讯作者：
Wilson, Richard K.