Differential processing of a chemosensory cue across life stages sharing the same valence state in Caenorhabditis elegans.
Differential processing of a chemosensory cue across life stages sharing the same valence state in Caenorhabditis elegans.
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DOI：
10.1073/pnas.2218023120
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发表时间：
2023-05-09
影响因子：
11.1
通讯作者：
Hallem, Elissa A.
中科院分区：
文献类型：
--
作者：
Banerjee, Navonil;Shih, Pei-Yin;Palato, Elisa J. Rojas;Sternberg, Paul W.;Hallem, Elissa A.
Animals frequently show the same preference toward a chemosensory cue under widely varying external and internal conditions. Whether such chemosensory cues involve similar neural mechanisms across conditions is unclear. Here, we show that carbon dioxide (CO2) is processed through distinct neural mechanisms in C. elegans at two different life stages that show the same preference for CO2. These mechanistic differences are manifested in altered CO2-evoked neuronal activity and motor output. A life stage–specific change in neural connectivity and insulin signaling contribute to these circuit differences by modulating the functional properties of an interneuron. We demonstrate that distinct neural mechanisms may underlie the same preference for a chemosensory cue and highlight the importance of physiological context in understanding chemosensory behaviors. Many chemosensory cues evoke responses of the same valence under widely varying physiological conditions. It remains unclear whether similar or distinct neural mechanisms are involved in the detection and processing of such chemosensory cues across contexts. We show that in Caenorhabditis elegans, a chemosensory cue is processed by distinct neural mechanisms at two different life stages that share the same valence state. Both starved adults and dauer larvae are attracted to carbon dioxide (CO2), but CO2 evokes different patterns of neural activity and different motor outputs at the two life stages. Moreover, the same interneuron within the CO2 microcircuit plays a different role in driving CO2-evoked motor output at the two life stages. The dauer-specific patterns of CO2-evoked activity in this interneuron require a dauer-specific gap junction complex and insulin signaling. Our results demonstrate that functionally distinct microcircuits are engaged in response to a chemosensory cue that triggers the same valence state at different life stages, revealing an unexpected complexity to chemosensory processing.
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DOI：
10.1016/j.cub.2017.07.023
发表时间：
2017-09-11
期刊：
Current biology : CB
影响因子：
--
作者：
Guillermin ML;Carrillo MA;Hallem EA
通讯作者：
Hallem EA
影响因子：
6.7
作者：
Castelletto ML;Gang SS;Okubo RP;Tselikova AA;Nolan TJ;Platzer EG;Lok JB;Hallem EA
通讯作者：
Hallem EA
影响因子：
16.2
作者：
Flavell, Steven W.;Gogolla, Nadine;Lovett-Barron, Matthew;Zelikowsky, Moriel
通讯作者：
Zelikowsky, Moriel
DOI：
10.1523/jneurosci.4541-12.2013
发表时间：
2013-06-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Carrillo MA;Guillermin ML;Rengarajan S;Okubo RP;Hallem EA
通讯作者：
Hallem EA
影响因子：
64.5
作者：
Gordus, Andrew;Pokala, Navin;Bargmann, Cornelia I.
通讯作者：
Bargmann, Cornelia I.