Sex differences in time trends of colorectal cancer in England and Wales: the possible effect of female hormonal factors.
Sex differences in time trends of colorectal cancer in England and Wales: the possible effect of female hormonal factors.
复制标题
DOI：
10.1038/bjc.1996.120
复制
发表时间：
1996-03
影响因子：
8.8
通讯作者：
Swerdlow, AJ
中科院分区：
文献类型：
--
作者：
Silva, ID;Swerdlow, AJ
在英格兰和威尔士，1962-87年结直肠癌发病率和1960-91年死亡率的时间趋势的性别差异与女性荷尔蒙因素的变化有关。这种肿瘤的性别比有一种趋势，尤其是在降结肠，女性在年轻时的过度风险几乎消失了，而男性在老年时的过度风险增加了。这一趋势始于1920年代以后出生的人群，与口服避孕药的使用增加相吻合，在较小程度上也与生育率的增加相吻合。这一下降在1935年至1939年出生的年轻女性中尤为明显，同时口服避孕药的使用范围也扩大到更年轻的年龄段。这些结果与女性荷尔蒙因素可能在结直肠癌的病因中发挥作用的假设一致，也与口服避孕药可能在降结肠发挥保护作用的可能性一致。
Differences between the sexes in time trends of colorectal cancer incidence 1962-87 and mortality 1960-91 in England and Wales are examined in relation to changes in female hormonal factors. There was a trend in the sex ratio of this tumour, particularly marked for the descending colon, whereby the female excess in risk at young ages has almost disappeared but the male excess at older ages has increased. This trend started for cohorts born since the 1920s and coincided with the increase in the use of oral contraceptives and, to a lesser extent, with increases in fertility. The decline has been particularly pronounced for women at young ages born since 1935-39, coinciding with the spread of oral contraceptive use to younger age groups. These results are consistent with the hypothesis that female hormonal factors may play a role in the aetiology of colorectal cancer and with the possibility that oral contraceptive use might exert a protective effect in the descending colon.
登录
查看更多内容
影响因子：
5
作者：
KUNE, GA;KUNE, S;WATSON, LF
通讯作者：
WATSON, LF
影响因子：
2.3
作者：
JACOBS, EJ;WHITE, E;WEISS, NS
通讯作者：
WEISS, NS
影响因子：
8.8
作者：
SILVA, ID;SWERDLOW, AJ
通讯作者：
SWERDLOW, AJ
影响因子：
8.8
作者：
SWERDLOW, AJ
通讯作者：
SWERDLOW, AJ
影响因子：
10.3
作者：
HOEL, DG;DAVIS, DL;SWERDLOW, AJ
通讯作者：
SWERDLOW, AJ