Associations of Genetic Polymorphisms of mTOR rs2295080 T/G and rs1883965 G/A with Susceptibility of Urinary System Cancers.
Associations of Genetic Polymorphisms of mTOR rs2295080 T/G and rs1883965 G/A with Susceptibility of Urinary System Cancers.
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DOI：
10.1155/2022/1720851
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Min Z;Mi Y;Lv Z;Sun Y;Tang B;Wu H;Zhang Z;Pan H;Zhang Y;Lu C;Zuo L;Zhang L
哺乳动物雷帕霉素靶蛋白（mTOR）信号转导轴基因多态性可影响肿瘤的易感性。mTOR基因变体rs 2295080 T/G和rs 1883965 G/A与癌症风险之间的关系仍然不一致。本研究旨在全面调查mTOR多态性与癌症易感性之间的关系。 我们使用比值比（OR）、相应的95%置信区间（CI）和计算机模拟工具进行了全面评估，以评估mTOR变异的影响。采用免疫组化染色（IHS）和GSEA分析检测mTOR在泌尿系肿瘤中的表达。 这项研究共涉及22项病例对照研究，包括14，747名癌症患者和16，399名对照。rs 2295080 T/G多态性与癌症风险相关（G等位基因与T等位基因的OR = 0.89，95%CI = 0.80-0.98，P = 0.023; GT与TT的OR = 0.88，95%CI = 0.81-0.96，P = 0.004; GG+GT vs TT，OR = 0.87，95%CI = 0.78-0.96，P = 0.008），尤其是泌尿系统、乳腺和血液癌。rs 1883965 G/A变异与癌症易感性相关，尤其是消化道癌。IHS分析显示mTOR在前列腺癌和膀胱癌中上调。GSEA显示胰岛素信号通路、赖氨酸降解通路和mTOR信号通路在高mTOR表达组中富集。 mTOR rs 2295080 T/G多态性可能与泌尿系肿瘤的易感性有关。mTOR的表达与前列腺癌的恶性程度呈正相关。
Genetic polymorphisms in mammalian target of rapamycin (mTOR) signaling axis can influence the susceptibility of cancer. The relationship between mTOR gene variants rs2295080 T/G and rs1883965 G/A and the risk of cancer remains inconsistent. The present study is aimed at comprehensively investigating the association between mTOR polymorphisms and susceptibility to cancer. We conducted a comprehensive assessment using odds ratios (ORs), corresponding 95% confidence intervals (CIs), and in silico tools to evaluate the effect of mTOR variations. Immunohistochemical staining (IHS) and GSEA analysis were used to investigate the expression of mTOR in urinary system cancer. The pooled analysis involved 22 case-control studies including 14,747 cancer patients and 16,399 controls. The rs2295080 T/G polymorphism was associated with the risk of cancer (G-allele versus T-allele, OR = 0.89, 95%CI = 0.80–0.98, P = 0.023; GT versus TT, OR = 0.88, 95%CI = 0.81–0.96, P = 0.004; GG+GT versus TT, OR = 0.87, 95%CI = 0.78–0.96, P = 0.008), especially for cancers of the urinary system, breast, and blood. Variation rs1883965 G/A was associated with cancer susceptibility, especially for digestive cancer. IHS analysis showed that mTOR was upregulated in prostate and bladder cancer. GSEA revealed that the insulin signaling pathway, lysine degradation pathway, and mTOR signaling pathway were enriched in the high mTOR expression group. The mTOR rs2295080 T/G polymorphism may be associated with susceptibility of urinary cancer. The expression of mTOR is positively correlated with tumor malignancy in prostate cancer.
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影响因子：
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作者：
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