Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.
Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.
复制标题
DOI：
10.1016/j.drudis.2014.04.017
复制
发表时间：
2014-06
影响因子：
7.4
通讯作者：
Borenstein, Jeffrey T.
中科院分区：
文献类型：
--
作者：
Ebrahimkhani, Mohammad R.;Young, Carissa L.;Lauffenburger, Douglas A.;Griffith, Linda G.;Borenstein, Jeffrey T.
捕获体内组织行为复杂性的可靠体外人类疾病模型对于获得对人类疾病的机制见解并能够开发在广泛患者人群中有效的治疗方法至关重要。干细胞技术、组织工程、新兴生物材料策略和微制造工艺以及计算和系统生物学方法的整合，使新的工具能够产生可靠的体外系统，以研究人类疾病的分子基础并促进药物开发。在这篇综述中，我们讨论了这些最近开发的工具，并强调了将这些技术结合到再生科学中所面临的机遇和挑战。
Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science.
登录
查看更多内容
人肝细胞中与细胞因子相关的药物毒性与信号网络失调有关。
影响因子：
--
作者：
Cosgrove, Benjamin D.;Alexopoulos, Leonidas G.;Hang, Ta-chun;Hendriks, Bart S.;Sorger, Peter K.;Griffith, Linda G.;Lauffenburger, Douglas A.
通讯作者：
Lauffenburger, Douglas A.
影响因子：
17.1
作者：
Baxter, Kristin;Horn, Elizabeth;Terry, Sharon F.
通讯作者：
Terry, Sharon F.
影响因子：
46.9
作者：
Chambers, Stuart M.;Fasano, Christopher A.;Papapetrou, Eirini P.;Tomishima, Mark;Sadelain, Michel;Studer, Lorenz
通讯作者：
Studer, Lorenz
影响因子：
6.1
作者：
Curran, Judith M.;Stokes, Robert;Hunt, John A.
通讯作者：
Hunt, John A.
影响因子：
3.8
作者：
Cosgrove, Benjamin D.;King, Bracken M.;Lauffenburger, Douglas A.
通讯作者：
Lauffenburger, Douglas A.