Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma.
Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma.
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DOI：
10.1002/hed.21810
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发表时间：
2012-05
影响因子：
2.9
通讯作者：
Lokeshwar, Vinata B.
中科院分区：
文献类型：
--
作者：
Franzmann, Elizabeth J.;Reategui, Erika P.;Pereira, Lutecia H. Mateus;Pedroso, Felipe;Joseph, Debbie;Allen, Glenn O.;Hamilton, Kara;Reis, Isildinha;Duncan, Robert;Goodwin, W. Jarrard;Hu, Jennifer J.;Lokeshwar, Vinata B.
头颈鳞状细胞癌 (HNSCC) 是一种毁灭性的疾病，通常在晚期才被诊断出来，治愈率仅为 40%。我们研究了一种简单且廉价的分子工具，可以帮助检测 HNSCC。基于之前的研究结果，即 102 例 HNSCC 病例与 84 例对照病例中的总蛋白水平升高，我们进一步分析了这些水平的重要风险和人口统计学变量，并将结果与 solCD44 进行了比较。使用多元自适应回归样条 (MARS)-logit 建模和逻辑回归，我们确定了总蛋白、solCD44 或其组合是否能最好地识别 HNSCC。 solCD44 和蛋白质的联合较高水平与 HNSCC 显着相关（OR=24.90 95%CI 9.04, 68.57，AUC=0.786）。包含蛋白质加 solCD44 的模型比单独使用任一标记物产生更好的曲线下面积 (0.796)。口腔冲洗液中 solCD44 和蛋白质的水平似乎有望用于检测 HNSCC。
Head and neck squamous cell carcinoma (HNSCC) is a devastating disease usually diagnosed at late stage when cure rates are 40%. We examined a simple and inexpensive molecular tool that may aid HNSCC detection. Building on prior findings that total protein levels are elevated in 102 HNSCC cases versus 84 controls, we further analyzed these levels with respect to important risk and demographic variables and compared results to solCD44. Using Multivariate Adaptive Regression Splines (MARS)-logit modeling and logistic regression, we determined whether total protein, solCD44 or the combination best identifies HNSCC. Combined higher levels of solCD44 and protein were significantly associated with HNSCC (OR=24.90 95%CI 9.04, 68.57, AUC=0.786). A model including protein plus solCD44 resulted in a better area under the curve (0.796) than either marker alone. Oral rinse levels of solCD44 and protein appear to hold promise for detection of HNSCC.
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影响因子：
6.4
作者：
Chang, Steven S.;Jiang, Wei Wen;Smith, Ian;Poeta, Luana M.;Begum, Shahnaz;Glazer, Chad;Shan, Shannon;Westra, William;Sidransky, David;Califano, Joseph A.
通讯作者：
Califano, Joseph A.
DOI：
10.1158/1078-0432.ccr-08-3131
发表时间：
2009-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Avissar M;Christensen BC;Kelsey KT;Marsit CJ
通讯作者：
Marsit CJ
影响因子：
3.8
作者：
Linkov, Faina;Lisovich, Alex;Ferris, Robert L.
通讯作者：
Ferris, Robert L.
影响因子：
5
作者：
Guha, Neela;Boffetta, Paolo;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
11.2
作者：
Kozaki, Ken-ichi;Imoto, Issei;Inazawa, Johji
通讯作者：
Inazawa, Johji