Astrocytes and Glutamine Synthetase in Epileptogenesis.
Astrocytes and Glutamine Synthetase in Epileptogenesis.
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DOI：
10.1002/jnr.24267
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发表时间：
2019-11
影响因子：
4.2
通讯作者：
Zaveri HP
中科院分区：
文献类型：
--
作者：
Eid T;Lee TW;Patrylo P;Zaveri HP
The cellular, molecular and metabolic mechanisms that underlie the development of mesial temporal lobe epilepsy are incompletely understood. Here we review the role of astrocytes in epilepsy development (a.k.a. epileptogenesis), particularly astrocyte pathologies related to: aquaporin 4, the inwardly rectifying potassium channel Kir4.1, monocarboxylate transporters MCT1 and MCT2, excitatory amino acid transporters EAAT1 and EAAT2, and glutamine synthetase. We propose that inhibition, dysfunction or loss of astrocytic glutamine synthetase is an important causative factor for some epilepsies, particularly mesial temporal lobe epilepsy and glioblastoma-associated epilepsy. We postulate that the regulatory mechanisms of glutamine synthetase as well as the downstream effects of glutamine synthetase dysfunction, represent attractive, new targets for antiepileptogenic interventions. Currently, no antiepileptogenic therapies are available for human use. The discovery of such interventions is important as it will fundamentally change the way we approach epilepsy by preventing the disease from ever becoming manifest after an epileptogenic insult to the brain.
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影响因子：
3.4
作者：
Constable RT;Scheinost D;Finn ES;Shen X;Hampson M;Winstanley FS;Spencer DD;Papademetris X
通讯作者：
Papademetris X
影响因子：
5.3
作者：
Albright B;Dhaher R;Wang H;Harb R;Lee TW;Zaveri H;Eid T
通讯作者：
Eid T
影响因子：
6.1
作者：
Bjornsen, L. P.;Eid, T.;de Lanerolle, N. C.
通讯作者：
de Lanerolle, N. C.
影响因子：
3.6
作者：
Butterworth, Roger F.
通讯作者：
Butterworth, Roger F.
影响因子：
2.2
作者：
Alvestad, Silje;Hammer, Janniche;Ottersen, Ole Petter
通讯作者：
Ottersen, Ole Petter