Potential use and challenges of functional connectivity mapping in intractable epilepsy.
Potential use and challenges of functional connectivity mapping in intractable epilepsy.
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DOI：
10.3389/fneur.2013.00039
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发表时间：
2013
影响因子：
3.4
通讯作者：
Papademetris X
中科院分区：
文献类型：
--
作者：
Constable RT;Scheinost D;Finn ES;Shen X;Hampson M;Winstanley FS;Spencer DD;Papademetris X
本文综述了静息态功能磁共振成像技术在评估人脑功能连接性方面的应用及其在难治性癫痫中的应用。这种方法有可能根据术前大脑的功能组织来预测给定外科手术的结果。功能连接还可以识别癫痫患者中组织不同的皮层区域，无论是作为疾病的直接功能还是通过间接的代偿反应。功能连接映射可以帮助识别致癫痫组织，无论这是一个单一的病灶位置或网络的致癫痫组织。这篇评论涵盖了连通性分析的基础知识，并讨论了与分析此类数据相关的特定问题。这些问题包括如何定义节点，以及单个节点、节点组的连接性分析和体素级别的全脑评估之间的差异。任意阈值在一些连接分析的需要进行了讨论，并审查了这个问题的解决方案。总体而言，功能连接分析正在成为评估癫痫患者脑组织功能的重要工具。
This review focuses on the use of resting-state functional magnetic resonance imaging data to assess functional connectivity in the human brain and its application in intractable epilepsy. This approach has the potential to predict outcomes for a given surgical procedure based on the pre-surgical functional organization of the brain. Functional connectivity can also identify cortical regions that are organized differently in epilepsy patients either as a direct function of the disease or through indirect compensatory responses. Functional connectivity mapping may help identify epileptogenic tissue, whether this is a single focal location or a network of seizure-generating tissues. This review covers the basics of connectivity analysis and discusses particular issues associated with analyzing such data. These issues include how to define nodes, as well as differences between connectivity analyses of individual nodes, groups of nodes, and whole-brain assessment at the voxel level. The need for arbitrary thresholds in some connectivity analyses is discussed and a solution to this problem is reviewed. Overall, functional connectivity analysis is becoming an important tool for assessing functional brain organization in epilepsy.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
2.2
作者：
Andrzejak, RG;Mormann, F;Lehnertz, K
通讯作者：
Lehnertz, K
DOI：
10.1007/s004060050081
发表时间：
1999-06-01
影响因子：
4.7
作者：
Crespo-Facorro, B;Cabranes, JA;Lopez-Ibor, JJ
通讯作者：
Lopez-Ibor, JJ
影响因子：
6
作者：
Frings, Lars;Schulze-Bonhage, Andreas;Wagner, Kathrin
通讯作者：
Wagner, Kathrin
影响因子：
9.9
作者：
Bai, X.;Guo, J.;Blumenfeld, H.
通讯作者：
Blumenfeld, H.