comoRbidity: an R package for the systematic analysis of disease comorbidities.
comoRbidity: an R package for the systematic analysis of disease comorbidities.
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DOI：
10.1093/bioinformatics/bty315
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发表时间：
2018-09-15
期刊：
影响因子：
--
通讯作者：
Furlong LI
中科院分区：
文献类型：
--
作者：
Gutiérrez-Sacristán A;Bravo À;Giannoula A;Mayer MA;Sanz F;Furlong LI
合并症的研究是一个主要的优先事项，因为它们对预期寿命，生活质量和医疗费用的影响。用于数据挖掘的电子健康记录（EHR）的可用性提供了从常规医疗护理期间收集的患者的临床病史中发现疾病关联和合并症模式的机会。这就需要分析工具来检测疾病合并症，包括调查其潜在的遗传基础。我们提出了comoRisk，一个R包，旨在从临床和分子角度对疾病合并症进行系统和全面的分析。comoRisk利用（i）用户提供的来自EHR数据库的临床数据（临床共病分析）和（ii）研究疾病的基因型-表型信息（分子共病分析）对疾病共病进行综合分析。临床共病分析能够从临床数据中识别显著的疾病共病，包括性别和年龄分层以及时间方向性分析，而分子共病分析通过探索疾病之间的共享基因来支持关于疾病共病的潜在机制的假设的产生。开源comoRisk包是一种软件工具，旨在通过整合几种分析和可视化功能来加快疾病合并症的综合分析。 https://bitbucket.org/ibi_group/comorbidity 补充数据可在Bioinformatics在线获得。
The study of comorbidities is a major priority due to their impact on life expectancy, quality of life and healthcare cost. The availability of electronic health records (EHRs) for data mining offers the opportunity to discover disease associations and comorbidity patterns from the clinical history of patients gathered during routine medical care. This opens the need for analytical tools for detection of disease comorbidities, including the investigation of their underlying genetic basis. We present comoRbidity, an R package aimed at providing a systematic and comprehensive analysis of disease comorbidities from both the clinical and molecular perspectives. comoRbidity leverages from (i) user provided clinical data from EHR databases (the clinical comorbidity analysis) and (ii) genotype-phenotype information of the diseases under study (the molecular comorbidity analysis) for a comprehensive analysis of disease comorbidities. The clinical comorbidity analysis enables identifying significant disease comorbidities from clinical data, including sex and age stratification and temporal directionality analyses, while the molecular comorbidity analysis supports the generation of hypothesis on the underlying mechanisms of the disease comorbidities by exploring shared genes among disorders. The open-source comoRbidity package is a software tool aimed at expediting the integrative analysis of disease comorbidities by incorporating several analytical and visualization functions. https://bitbucket.org/ibi_group/comorbidity Supplementary data are available at Bioinformatics online.
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