Adamts18 modulates the development of the aortic arch and common carotid artery.
Adamts18 modulates the development of the aortic arch and common carotid artery.
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DOI：
10.1016/j.isci.2021.102672
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发表时间：
2021-06-25
期刊：
影响因子：
5.8
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Ye S;Yang N;Lu T;Wu T;Wang L;Pan YH;Cao X;Yuan X;Wisniewski T;Dang S;Zhang W
具有血小板反应蛋白基序的去整合素和金属蛋白酶（ADAMTS）家族的成员已经涉及各种血管疾病。然而，它们在早期胚胎血管发育中的功能作用尚不清楚。在这项研究中，我们发现Adamts 18在E11.5-E14.5在小鼠鳃弓动脉发育过程中胚胎主动脉弓（AOAR）和颈总动脉（CCA）周围的细胞中高度表达。Adamts 18缺乏可导致AOAR、CCA、第三和第四鳃弓附件发育异常，导致颈动脉体、胸腺发育不良，大脑中动脉变异。Adamts 18显示影响AOAR和CCA周围细胞外基质（ECM）组分，特别是纤连蛋白（Fn）的积累。由于Fn积累增加，Notch 3信号通路被激活以促进颅神经嵴细胞（CNCC）向血管平滑肌细胞的分化。这些数据表明，Adamts 18介导的ECM稳态对于CNCC的分化至关重要。Adamts 18在胚胎颈动脉形成期间高表达Adamts 18缺陷导致异常AOAR、CCA、MCA分支和颈动脉附件Adamts 18缺陷改变小鼠tMCAO模型的脑梗死面积Adamts 18通过调节Notch 3通路影响CNCC向VSMC的分化细胞生物学;发育生物学;
Members of a disintegrin and metalloproteinases with thrombospondin motif (ADAMTS) family have been implicated in various vascular diseases. However, their functional roles in early embryonic vascular development are unknown. In this study, we showed that Adamts18 is highly expressed at E11.5-E14.5 in cells surrounding the embryonic aortic arch (AOAR) and the common carotid artery (CCA) during branchial arch artery development in mice. Adamts18 deficiency was found to cause abnormal development of AOAR, CCA, and the third and fourth branchial arch appendages, leading to hypoplastic carotid body, thymus, and variation of middle cerebral artery. Adamts18 was shown to affect the accumulation of extracellular matrix (ECM) components, in particular fibronectin (Fn), around AOAR and CCA. As a result of increased Fn accumulation, the Notch3 signaling pathway was activated to promote the differentiation of cranial neural crest cells (CNCCs) to vascular smooth muscle cells. These data indicate that Adamts18-mediated ECM homeostasis is crucial for the differentiation of CNCCs. Adamts18 is highly expressed during the period of embryonic carotid artery formation Adamts18 deficiency leads to abnormal AOAR, CCA, MCA branches and carotid appendages Adamts18 deficiency changes the cerebral infarcted areas in mouse tMCAO model Adamts18 affects the differentiation of CNCCs to VSMCs by modulating Notch3 pathway Cell biology; Developmental biology;
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影响因子：
4.6
作者：
Hubmacher D;Schneider M;Berardinelli SJ;Takeuchi H;Willard B;Reinhardt DP;Haltiwanger RS;Apte SS
通讯作者：
Apte SS
影响因子：
2.7
作者：
Dupuis LE;McCulloch DR;McGarity JD;Bahan A;Wessels A;Weber D;Diminich AM;Nelson CM;Apte SS;Kern CB
通讯作者：
Kern CB
影响因子：
4.2
作者：
Lopez, Lorna M.;Bastin, Mark E.;Deary, Ian J.
通讯作者：
Deary, Ian J.
ADAMTS18 缺乏导致肺发育不全和支气管微纤维积聚
影响因子：
5.8
作者：
Lu, Tiantian;Lin, Xiaotian;Zhang, Wei
通讯作者：
Zhang, Wei
影响因子：
5.6
作者：
Mongiat M;Andreuzzi E;Tarticchio G;Paulitti A
通讯作者：
Paulitti A