Intracellular localization and unique conserved sequences of three small nucleolar RNAs.

Intracellular localization and unique conserved sequences of three small nucleolar RNAs.
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三种小核仁 RNA 的细胞内定位和独特保守序列。

DOI:
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发表时间:
1997
影响因子:
14.9
通讯作者:
G. L. Eliceiri
G. L. Eliceiri
中科院分区:
生物学2区
文献类型:
--
作者:
N. Selvamurugan;O. Joost;E. S. Haas;J. Brown;N. Galvin;G. L. Eliceiri

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Three human small nucleolar RNAs (snoRNAs), E1, E2 and E3, were reported earlier that have unique sequences, interact directly with unique segments of pre-rRNA in vivo and are encoded in introns of protein genes. In the present report, human and frog E1, E2 and E3 RNAs injected into the cytoplasm of frog oocytes migrated to the nucleus and specifically to the nucleolus. This indicates that the nucleolar and nuclear localization signals of these snoRNAs reside within their evolutionarily conserved segments. Homologs of these snoRNAs from several vertebrates were sequenced and this information was used to develop RNA secondary structure models. These snoRNAs have unique phylogenetically conserved sequences.
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