Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods.
Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods.
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DOI：
10.1093/neuonc/noac211
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发表时间：
2023-02-14
期刊：
影响因子：
15.9
通讯作者：
中科院分区：
文献类型：
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作者：
基因组和转录异质性在儿童和成人中最常见和侵袭性的原发性脑肿瘤中普遍存在。在过去的20年里，生物工程，生物化学和生物信息学的进步已经使一系列技术的发展，以单细胞分辨率研究肿瘤生物学。应用这些技术来研究原发性脑肿瘤有助于我们进一步了解它们的肿瘤内异质性，并揭示了关于它们的发育程序和微环境信号的共同选择以促进肿瘤增殖和侵袭的新见解。这些见解目前正被用来开发新的治疗方法。在这里，我们提供了当前单细胞技术的概述，并讨论了其应用于儿童和成人原发性脑肿瘤所揭示的相关生物学和治疗见解。
Genomic and transcriptional heterogeneity is prevalent among the most common and aggressive primary brain tumors in children and adults. Over the past 20 years, advances in bioengineering, biochemistry and bioinformatics have enabled the development of an array of techniques to study tumor biology at single-cell resolution. The application of these techniques to study primary brain tumors has helped advance our understanding of their intra-tumoral heterogeneity and uncover new insights regarding their co-option of developmental programs and signaling from their microenvironment to promote tumor proliferation and invasion. These insights are currently being harnessed to develop new therapeutic approaches. Here we provide an overview of current single-cell techniques and discuss relevant biology and therapeutic insights uncovered by their application to primary brain tumors in children and adults.
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DOI：
10.1158/1541-7786.mcr-16-0389
发表时间：
2017-09
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Cordero FJ;Huang Z;Grenier C;He X;Hu G;McLendon RE;Murphy SK;Hashizume R;Becher OJ
通讯作者：
Becher OJ
影响因子：
23.9
作者：
Funato K;Smith RC;Saito Y;Tabar V
通讯作者：
Tabar V
影响因子：
23.9
作者：
Bressan RB;Southgate B;Ferguson KM;Blin C;Grant V;Alfazema N;Wills JC;Marques-Torrejon MA;Morrison GM;Ashmore J;Robertson F;Williams CAC;Bradley L;von Kriegsheim A;Anderson RA;Tomlinson SR;Pollard SM
通讯作者：
Pollard SM
影响因子：
48
作者：
Angermueller C;Clark SJ;Lee HJ;Macaulay IC;Teng MJ;Hu TX;Krueger F;Smallwood S;Ponting CP;Voet T;Kelsey G;Stegle O;Reik W
通讯作者：
Reik W
影响因子：
46.9
作者：
Cadwell CR;Palasantza A;Jiang X;Berens P;Deng Q;Yilmaz M;Reimer J;Shen S;Bethge M;Tolias KF;Sandberg R;Tolias AS
通讯作者：
Tolias AS