Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B
Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B
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血清单不饱和三酰甘油可预测非酒精性脂肪肝和慢性乙型肝炎患者的脂肪性肝炎
DOI：
10.1038/s41598-017-11278-x
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发表时间：
2017-09
影响因子：
4.6
通讯作者：
Fan Jian-gao
中科院分区：
文献类型：
--
作者：
Yang Rui-xu;Hu Chun-xiu;Sun Wan-lu;Pan Qin;Shen Feng;Yang Zhen;Su Qing;Xu Guo-wang;Fan Jian-gao
慢性肝病与脂质代谢紊乱有关。我们进行了一项研究，以确定非酒精性脂肪性肝病（NAFLD）和活动性慢性肝炎B（CH B）患者的血清脂质组学特征，并探讨非酒精性脂肪性肝炎（NASH）的生物标志物。采用超高效液相色谱-串联质谱法分析健康对照组（n= 23）、经活检证实的NAFLD组（n= 42）、CHB伴NAFLD组（n= 22）和无NAFLD组（n= 17）的血清脂质组学特征。NAFLD组与CHB非NAFLD组之间血脂水平差异有统计学意义。NAFLD组中性脂质和神经酰胺水平升高，而CHB无NAFLD组中性脂质和神经酰胺水平降低。两组的缩醛磷脂均减少。在NASH受试者中，具有较低碳数和双键的三酰甘油（TAG）增加。血清单不饱和TAG是NASH的重要预测因子（OR = 3.215; 95%CI 1.663-6.331），与组织学活动性呈正相关（r = 0.501;P< 0.001）。在NAFLD组中显示出对NASH的良好预测性[受试者工作特征曲线下面积（AUROC）= 0.831]，并在CHB组中得到验证（AUROC = 0.833）;该特征上级于细胞角蛋白-18和丙氨酸转氨酶。单不饱和TAG的增加可能是NAFLD和CHB患者中NASH的特异性标志物。
Chronic liver disease is associated with lipid metabolic disruption. We carried out a study to determine serum lipidomic features of patients with non-alcoholic fatty liver disease (NAFLD) and active chronic hepatitis B (CHB) and explored the biomarkers for non-alcoholic steatohepatitis (NASH). Serum lipidomic profiles of healthy controls (n= 23) and of biopsy–proven NAFLD (n= 42), CHB with NAFLD (n= 22) and without NAFLD (n= 17) were analyzed by ultra-performance liquid chromatography–tandem mass spectrometry. There were distinct serum lipidome between groups of NAFLD and CHB without NAFLD. Most of the neutral lipids and ceramide were elevated in the NAFLD group but were decreased in the CHB without NAFLD group. Plasmalogens were decreased in both groups. Triacylglycerols (TAGs) with lower carbon numbers and double bonds were increased in subjects with NASH. Serum monounsaturated TAG was a significant predictor of NASH (OR = 3.215; 95%CI 1.663–6.331) and positively correlated with histological activity (r = 0.501;P< 0.001). It showed good predictability for NASH in the NAFLD group [area under the receiver operating characteristic curves (AUROC) = 0.831] and was validated in the CHB group (AUROC = 0.833); this characteristic was superior to that of cytokeratin-18 and alanine transaminase. The increase in monounsaturated TAG might be a specific marker for NASH in both NAFLD and CHB patients.
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影响因子：
6.9
作者：
Chiang, Chien-Hsieh;Lai, Jin-Shin;Huang, Kuo-Chin
通讯作者：
Huang, Kuo-Chin
影响因子：
13.5
作者：
Chia-Chi Wang;J. Kao
通讯作者：
Chia-Chi Wang;J. Kao
影响因子：
13.5
作者：
Joo, Eun-Jeong;Chang, Yoosoo;Ryu, Seungho
通讯作者：
Ryu, Seungho
DOI：
--
发表时间：
2018
期刊：
--
影响因子：
--
作者：
Y. Zhai;Xin Chen;Xin Liu;Zhi-qiang Zhang;H. Xiao;Gang Liu
通讯作者：
Y. Zhai;Xin Chen;Xin Liu;Zhi-qiang Zhang;H. Xiao;Gang Liu
DOI：
--
发表时间：
2016
期刊：
--
影响因子：
--
作者：
B. Ghonsooly;R. Pishghadam
通讯作者：
B. Ghonsooly;R. Pishghadam