Regulation of Embryonic Blood Vessel Formation
Regulation of Embryonic Blood Vessel Formation
复制标题
胚胎血管形成的调节
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
W. Risau
中科院分区：
文献类型：
--
作者：
H. Drexler;H. Schnürch;G. Breier;W. Risau
正常成人组织内的内皮细胞更新通常非常低，在数月甚至数年的范围内（Denekamp，1984）。相反，与肿瘤血管形成有关的血管内皮细胞的增殖率非常高，并且在几天的范围内（Engermann et al.，1967年）。新血管的大量形成并不是肿瘤发展的唯一特征，但也发生在其他病理条件下，如糖尿病视网膜病变或类风湿性关节炎。也可以在伤口愈合期间以及在女性成年人的排卵和黄体形成期间观察到，但在这些情况下，血管生成过程似乎受到防止过度反应的控制机制的调节。这种受控的血管生成过程可以被称为生理性血管生成，以将其与各种病理条件下血管的异常形成区分开来。
Endothelial cell turnover within normal adult tissues generally appears to be very low and is in the range of months or even years (Denekamp, 1984). In contrast, the proliferation rate of endothelial cells lining the blood vessels that are involved in tumor vascularization is very high and in the range of a few days (Engermann et al., 1967). The massive formation of new blood vessels is not an exclusive characteristic of tumor development, but also occurs in other pathological conditions like diabetic retinopathies or rheumatoid arthritis. It can also be observed during wound healing as well as during ovulation and corpus luteum formation in the female adult, but in these instances the angiogenic process seems to be regulated by control mechanisms that prevent an overshooting reaction. This controlled angiogenic process may be termed physiological angiogenesis to distinguish it from the aberrant formation of blood vessels under various pathological conditions.
影响因子：
4.6
作者：
A. Wanaka;J. Milbrandt;Eugene M. Johnson
通讯作者：
A. Wanaka;J. Milbrandt;Eugene M. Johnson
影响因子：
2.7
作者：
RISAU, W;LEMMON, V
通讯作者：
LEMMON, V