d-Propranolol protects against oxidative stress and progressive cardiac dysfunction in iron overloaded rats.
d-Propranolol protects against oxidative stress and progressive cardiac dysfunction in iron overloaded rats.
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d-普萘洛尔可防止铁超载大鼠的氧化应激和进行性心脏功能障碍。
DOI：
10.1139/y2012-091
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发表时间：
2012
影响因子：
2.1
通讯作者：
Weglicki,WilliamB
中科院分区：
文献类型：
--
作者：
Kramer,JayH;Spurney,ChristopherF;Iantorno,Micaela;Tziros,Constantine;Chmielinska,JoannaJ;Mak,ITong;Weglicki,WilliamB
d-Propranolol (d-Pro: 2–8 mg·(kg body mass)–1·day–1) protected against cardiac dysfunction and oxidative stress during 3–5 weeks of iron overload (2 mg Fe–dextran·(g body mass)–1·week–1) in Sprague–Dawley rats. At 3 weeks, hearts were perfused in working mode to obtain baseline function; red blood cell glutathione, plasma 8-isoprostane, neutrophil basal superoxide production, lysosomal-derived plasmaN-acetyl-β-galactosaminidase (NAGA) activity, ventricular iron content, and cardiac iron deposition were assessed. Hearts from the Fe-treated group of rats exhibited lower cardiac work (26%) and output (CO, 24%); end-diastolic pressure rose 1.8-fold. Further, glutathione levels increased 2-fold, isoprostane levels increased 2.5-fold, neutrophil superoxide increased 3-fold, NAGA increased 4-fold, ventricular Fe increased 4.9-fold; and substantial atrial and ventricular Fe-deposition occurred.d-Pro (8 mg) restored heart function to the control levels, protected against oxidative stress, and decreased cardiac Fe levels. After 5 weeks of Fe treatment, echocardiography revealed that the following were depressed: percent fractional shortening (%FS, 31% lower); left ventricular (LV) ejection fraction (LVEF, 17%), CO (25%); and aortic pressure maximum (Pmax, 24%). Mitral valveE/Adeclined by 18%, indicating diastolic dysfunction. Cardiac CD11b+ infiltrates were elevated. Lowd-Pro (2 mg) provided modest protection, whereas 4–8 mg greatly improved LVEF (54%–75%), %FS (51%–81%), CO (43%–78%),Pmax(56%–100%), andE/A>100%; 8 mg decreased cardiac inflammation. Sinced-Pro is an antioxidant and reduces cardiac Fe uptake as well as inflammation, these properties may preserve cardiac function during Fe overload.
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DOI：
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发表时间：
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