Apoptotic Cell Clearance in Drosophila melanogaster.
Apoptotic Cell Clearance in Drosophila melanogaster.
复制标题
果蝇中的凋亡细胞清除
DOI：
10.3389/fimmu.2017.01881
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发表时间：
2017
影响因子：
7.3
通讯作者：
Xiao H
中科院分区：
文献类型：
--
作者：
Zheng Q;Ma A;Yuan L;Gao N;Feng Q;Franc NC;Xiao H
吞噬细胞迅速清除凋亡细胞（AC）（吞噬作用）是所有多细胞生物发育过程中的关键事件。它通过专业或业余吞噬细胞的吞噬作用实现。这个过程的失败可能导致炎症性自身免疫或神经退行性疾病的发展。AC清除在整个进化过程中一直是保守的，尽管其机制中的许多细节仍有待探索。它已经在哺乳动物巨噬细胞的背景下进行了研究，并在线虫秀丽隐杆线虫中进行了研究，秀丽隐杆线虫缺乏“专业”吞噬细胞，如巨噬细胞，但其他细胞类型可以吞噬凋亡的尸体。在黑腹果蝇中，AC被巨噬细胞、神经胶质细胞和上皮细胞吞噬。果蝇巨噬细胞的功能与哺乳动物巨噬细胞相似。它们是参与吞噬AC和病原体的专职吞噬细胞。对果蝇AC清除的研究已经确定了一些关键因素，例如受体Croquemort和德雷珀，促进果蝇成为从基因上剖析这一过程的合适模型。本文综述了近年来果蝇AC清除途径的研究进展，并讨论了这一过程的生理结果和后果。
The swift clearance of apoptotic cells (ACs) (efferocytosis) by phagocytes is a critical event during development of all multicellular organisms. It is achieved through phagocytosis by professional or amateur phagocytes. Failure in this process can lead to the development of inflammatory autoimmune or neurodegenerative diseases. AC clearance has been conserved throughout evolution, although many details in its mechanisms remain to be explored. It has been studied in the context of mammalian macrophages, and in the nematode Caenorhabditis elegans, which lacks “professional” phagocytes such as macrophages, but in which other cell types can engulf apoptotic corpses. In Drosophila melanogaster, ACs are engulfed by macrophages, glial, and epithelial cells. Drosophila macrophages perform similar functions to those of mammalian macrophages. They are professional phagocytes that participate in phagocytosis of ACs and pathogens. Study of AC clearance in Drosophila has identified some key elements, like the receptors Croquemort and Draper, promoting Drosophila as a suitable model to genetically dissect this process. In this review, we survey recent works of AC clearance pathways in Drosophila, and discuss the physiological outcomes and consequences of this process.
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