Frailty, aging, and periodontal disease: Basic biologic considerations.
Frailty, aging, and periodontal disease: Basic biologic considerations.
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DOI：
10.1111/prd.12380
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发表时间：
2021-10
影响因子：
18.6
通讯作者：
Ramsay SE
中科院分区：
文献类型：
--
作者：
Clark D;Kotronia E;Ramsay SE
衰老与疾病的发展有关。牙周病是随着年龄的增长患病率增加的许多疾病和条件之一。除了传统上对个人与年龄有关的疾病的关注外，现在人们更多地认识到，脆弱等多系统疾病在老年人的健康中发挥着重要作用。虚弱是老年人的一种临床状况，它增加了不良健康后果的风险。虚弱和牙周病都是老年人群中常见的慢性疾病，并有几个共同的危险因素。牙周病和脆弱之间可能存在双向关系。在虚弱的老年人中，共病的全身性疾病、糟糕的身体功能和有限的自我照顾能力被认为是虚弱和牙周病之间的潜在联系。此外，虚弱和牙周病也与炎症失调和其他与年龄相关的病理生理变化有很强的相关性，这些变化可能同样是它们发生和发展的基础。研究调节炎症的免疫细胞与年龄相关的变化可能有助于更好地理解与年龄相关的疾病，并可能导致改善虚弱和牙周病管理的治疗目标。
Aging is associated with the development of disease. Periodontal disease is one of the many diseases and conditions that increase in prevalence with age. In addition to the traditional focus on individual age-related conditions, there is now a greater recognition that multi-system conditions such as frailty play an important role in the health of older populations. Frailty is a clinical condition in older adults, which increases the risk of adverse health outcomes. Both frailty and periodontal disease are common chronic conditions in older populations and share several risk factors. There is likely a bi-directional relationship between periodontal disease and frailty. Co-morbid systemic diseases, poor physical functioning, and limited ability to self-care in frail older people have been implicated to be underlying the association between frailty and periodontal disease. In addition, both frailty and periodontal disease also have strong associations with inflammatory dysregulation and other age-related pathophysiological changes that may similarly underlie their development and progression. Investigating age-related changes in immune cells that regulate inflammation may lead to a better understanding of age-related disease and could lead to therapeutic targets for the improved management of frailty and periodontal disease.
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影响因子：
78.5
作者：
Collado, Manuel;Serrano, Manuel
通讯作者：
Serrano, Manuel
DOI：
10.1083/jcb.201610113
发表时间：
2017-07-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Carroll B;Nelson G;Rabanal-Ruiz Y;Kucheryavenko O;Dunhill-Turner NA;Chesterman CC;Zahari Q;Zhang T;Conduit SE;Mitchell CA;Maddocks ODK;Lovat P;von Zglinicki T;Korolchuk VI
通讯作者：
Korolchuk VI
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
4.6
作者：
Aprahamian, T.;Takemura, Y.;Walsh, K.
通讯作者：
Walsh, K.
影响因子：
6.7
作者：
Ballou, SP;Lozanski, GB;Kushner, I
通讯作者：
Kushner, I