Transcriptional determinants of cancer immunotherapy response and resistance.
Transcriptional determinants of cancer immunotherapy response and resistance.
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DOI：
10.1016/j.trecan.2022.01.008
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发表时间：
2022-05
期刊：
影响因子：
18.4
通讯作者：
Wajapeyee N
中科院分区：
文献类型：
--
作者：
Gupta R;Mehta A;Wajapeyee N
宿主免疫反应是对抗癌症发生和进展的有效防御机制。因此，癌细胞必须发展出逃避免疫反应的机制才能生存。基于这些知识，一系列统称为免疫疗法的新疗法已经被开发出来并转化为临床用于治疗癌症患者。尽管某些癌症类型的子集已显示出强烈的临床反应，包括某些患者的治愈结果，但对于某些癌症亚型和形式，免疫疗法并未达到预期效果。在这里，我们概述了驱动免疫疗法反应和耐药的转录机制。我们还讨论了通过针对癌细胞中失调的转录网络来增强免疫疗法效果的可能干预措施。
The host immune response is a potent defense mechanism against cancer development and progression. Therefore, cancer cells must develop mechanisms to evade the immune response to survive. Based on this knowledge, a series of new therapies collectively referred to as immunotherapies have been developed and translated to the clinic for treating cancer patients. Although subsets of certain cancer types have shown strong clinical responses, including curative outcomes in some patients, for some subtypes and forms of cancers, immunotherapies have not worked as desired. Here, we provide an overview of the transcriptional mechanisms that drive response and resistance to immunotherapies. We also discuss possible interventions to enhance the outcomes of immunotherapies by targeting dysregulated transcription networks in cancer cells.
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影响因子：
82.9
作者：
Creelan BC;Wang C;Teer JK;Toloza EM;Yao J;Kim S;Landin AM;Mullinax JE;Saller JJ;Saltos AN;Noyes DR;Montoya LB;Curry W;Pilon-Thomas SA;Chiappori AA;Tanvetyanon T;Kaye FJ;Thompson ZJ;Yoder SJ;Fang B;Koomen JM;Sarnaik AA;Chen DT;Conejo-Garcia JR;Haura EB;Antonia SJ
通讯作者：
Antonia SJ
影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
6.4
作者：
Battaglia, Alessandra;Buzzonetti, Alexia;Fattorossi, Andrea
通讯作者：
Fattorossi, Andrea
DOI：
10.1073/pnas.2102718118
发表时间：
2021-07-27
影响因子：
11.1
作者：
Bugide, Suresh;Gupta, Romi;Wajapeyee, Narendra
通讯作者：
Wajapeyee, Narendra
DOI：
10.1038/s41568-021-00347-z
发表时间：
2021-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Hiam-Galvez KJ;Allen BM;Spitzer MH
通讯作者：
Spitzer MH