Microtubule nucleation by γ-tubulin complexes.
Microtubule nucleation by γ-tubulin complexes.
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DOI：
10.1038/nrm3209
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发表时间：
2011-10-12
期刊：
影响因子：
--
通讯作者：
Agard DA
中科院分区：
文献类型：
--
作者：
Kollman JM;Merdes A;Mourey L;Agard DA
Microtubule nucleation is controlled by the γ-tubulin ring complex (γTuRC) and related γ-tubulin complexes, providing spatial and temporal control over the initiation of microtubule growth. Recent structural work has shed light on the mechanism of γTuRC-based microtubule nucleation, confirming the long-standing hypothesis that it functions as a microtubule template. Crystallographic analysis of the first non-γ-tubulin γTuRC component (GCP4) has resulted in a new appreciation of the relationships among all γTuRC proteins, leading to a refined model of their organization and function. The structures have also suggested an unexpected mechanism for regulating γTuRC activity via conformational modulation of the complex component GCP3. New experiments on γTuRC localization extend these insights, suggesting a direct link between attachment at specific cellular sites and activation.
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影响因子：
3
作者：
Choy, Rebeca M.;Kollman, Justin M.;Zelter, Alex;Davis, Trisha N.;Agard, David A.
通讯作者：
Agard, David A.
DOI：
10.1083/jcb.135.1.5
发表时间：
1996-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Erickson HP;Stoffler D
通讯作者：
Stoffler D
DOI：
10.1126/science.1205193
发表时间：
2011-06-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Keck JM;Jones MH;Wong CC;Binkley J;Chen D;Jaspersen SL;Holinger EP;Xu T;Niepel M;Rout MP;Vogel J;Sidow A;Yates JR 3rd;Winey M
通讯作者：
Winey M
影响因子：
4.8
作者：
Izumi, Nanae;Fumoto, Katsumi;Kikuchi, Akira
通讯作者：
Kikuchi, Akira
影响因子：
3.3
作者：
Anders, Andreas;Lourenco, Paula C. C.;Sawin, Kenneth E.
通讯作者：
Sawin, Kenneth E.