Addressing the Challenges of Clinical Research for Freezing of Gait in Parkinson's Disease.
Addressing the Challenges of Clinical Research for Freezing of Gait in Parkinson's Disease.
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DOI：
10.1002/mds.28837
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
MDS Scientific Issues Committee
中科院分区：
文献类型：
--
作者：
Lewis SJG;Factor SA;Giladi N;Hallett M;Nieuwboer A;Nutt JG;Przedborski S;Papa SM;MDS Scientific Issues Committee
最近由国际帕金森和运动障碍协会科学问题委员会领导的科学小组讨论得出结论，应实施“系统生物学”策略，以促进我们对帕金森病（PD）步态和平衡障碍的病理生理学基础的理解。重要的是，未能理解与这些具有挑战性的症状相关的神经生物学过程被视为开发更成功的治疗方法的最重要障碍。科学小组还建议，应该重点开发可测试的实验模型，探索控制步态和姿势平衡的相互作用的回路和网络（详见Bohnen等人1）。使用先进的技术，这些模型将解决离散的机制假设，然后可以在人体测试阶段进行评估，采用自适应范式来验证临床病理生理学。然而，这种成功的研究将依赖于来自多个中心的大型数据集的严格性和质量，研究人员采用协调和标准化的方法。这样的研究计划需要非常仔细地考虑，特别是在临床环境中。因此，我们认为，
A recent Scientific Panel Discussion led by the Scientific Issues Committee of the International Parkinson and Movement Disorder Society has concluded that a “systems biology” strategy should be implemented to advance our understanding of the pathophysiology underpinning gait and balance disorders in Parkinson’s disease (PD). Critically, the failure to appreciate the neurobiological processes associated with these challenging symptoms is seen as the most significant barrier to the development of more successful therapeutic approaches. The Scientific Panel has also proposed that there should be a focus on the development of testable experimental models probing the interacting circuits and networks that control gait and postural balance (see details in Bohnen et al. 1). Using advanced technologies, these models would address discrete mechanistic hypotheses, which could then be evaluated in a human testing phase with adaptive paradigms to validate clinical pathophysiology. However, such successful research would rely on the rigor and quality of large datasets from multiple centers with investigators adopting a coordinated and standardized methodology. Such a program of research would need to be very carefully considered, especially in the clinical setting. Therefore,
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影响因子：
8.6
作者：
Bohnen, Nicolaas, I;Costa, Rui M.;Dauer, William T.;Factor, Stewart A.;Giladi, Nir;Hallett, Mark;Lewis, Simon J. G.;Nieuwboer, Alice;Nutt, John G.;Takakusaki, Kaoru;Kang, Un Jung;Przedborski, Serge;Papa, Stella M.
通讯作者：
Papa, Stella M.
影响因子：
5.3
作者：
Jacobs, Jesse V.;Nutt, John G.;Carlson-Kuhta, Patricia;Stephens, Marilee;Horak, Fay B.
通讯作者：
Horak, Fay B.
影响因子：
5.1
作者：
Mancini M;Shah VV;Stuart S;Curtze C;Horak FB;Safarpour D;Nutt JG
通讯作者：
Nutt JG
影响因子：
14.5
作者：
Georgiades, Matthew J.;Shine, James M.;Lewis, Simon J. G.
通讯作者：
Lewis, Simon J. G.
影响因子：
8.6
作者：
Manor, Brad;Dagan, Moria;Hausdorff, Jeffrey M.
通讯作者：
Hausdorff, Jeffrey M.