Angiogenesis-related molecular targets in esophageal cancer

Angiogenesis-related molecular targets in esophageal cancer
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食管癌血管生成相关分子靶点

DOI:
10.1517/13543784.2011.571203
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发表时间:
2011-04
期刊:
Expert Opin Investig Drugs
影响因子:
--
通讯作者:
D. Fan
D. Fan
中科院分区:
其他
文献类型:
--
作者:
L. Hong;S. Li;Y. Han;J. Du;H. Zhang;J. Li;Q. Zhao;K. Wu;D. Fan

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前言:血管生成因其在肿瘤生长和转移中的基础作用而成为肿瘤治疗的重要靶点。一些与血管生成相关的分子正在研究中,其中一些已经在临床实践中,结果各不相同。介绍和讨论血管生成相关分子靶点的研究现状将有助于改善食道癌(EC)患者的临床策略和预后。涉及的领域:本文综述了血管生成相关靶点在EC中的最新进展,并分析了它们提供的临床和治疗应用。我们展望了分子靶点抗血管生成策略的未来发展及其在癌症治疗中的潜在应用。专家观点:血管生成相关靶点可作为EC有用的治疗工具。应进行更多的研究,以促进抗血管生成治疗在临床试验中的成功。
Introduction: Angiogenesis has become an appealing target in cancer therapy due to its fundamental role in cancer growth and metastasis. A number of angiogenesis-related molecules are under investigation, with some already in clinical practice with various results. The effort to present and discuss the current status of the research on the angiogenesis-related molecular targets will lead to improved clinical strategies and outcomes for patients with esophageal cancer (EC). Areas covered : This review summarizes the recent advances in angiogenesis-related targets in EC, and also analyzes the clinical and therapeutic applications they provide. We envisage future developments towards the anti-angiogenic strategy of molecular targets and their potential applications to cancer treatment. Expert opinion : Angiogenesis-related targets can be used as a useful therapeutic tool for EC. More investigations should be performed to promote the success of anti-angiogenic therapy in clinical trials.
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