Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes.
Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes.
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DOI：
10.1002/acn3.51639
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发表时间：
2022-09
影响因子：
5.3
通讯作者：
Feldman, Eva L.
中科院分区：
文献类型：
--
作者：
Afshinnia, Farsad;Reynolds, Evan L.;Rajendiran, Thekkelnaycke M.;Soni, Tanu;Byun, Jaeman;Savelieff, Masha G.;Looker, Helen C.;Nelson, Robert G.;Michailidis, George;Callaghan, Brian C.;Pennathur, Subramaniam;Feldman, Eva L.
与2型糖尿病神经病变相关的血清脂质组学特征尚不清楚。肥胖和血脂异常是已知的神经病变危险因素，这表明2型糖尿病早期的血脂谱可能会识别出在病程后期发生神经病变的个体。这项回顾性队列研究检查了2型糖尿病神经病变评估前10年的脂质组学特征。参与者包括吉拉河印第安社区的2型糖尿病患者（n = 69），10年后使用密歇根神经病筛查仪（MNSI）检查和问卷评分进行了可用的血清样本和神经病变评估。一个综合MNSI指数计算考试和问卷分数。血清脂质（435种，从18类）进行了定量质谱。该队列包括17名男性和52名女性，平均年龄为45岁（SD = 9岁）。参与者被分层为有神经病变（高MNSI指数评分> 2.5407）与无神经病变（低MNSI指数评分≤ 2.5407）。基线时血清中中中链酰基肉毒碱显著减少和总游离脂肪酸增加（与链长和饱和度无关）与随访时周围神经病变事件相关，即参与者的MNSI指数评分较高，与协变量无关。神经病患者在基线时也有磷脂酰胆碱减少和溶血磷脂酰胆碱增加，与链长和饱和度无关。其他脂质类的丰度没有显着不同的神经病变状态。2型糖尿病患者神经病变评估前10年循环中酰基肉毒碱、游离脂肪酸、磷脂酰胆碱和溶血磷脂酰胆碱的显著差异与神经病变状态相关。
The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify individuals who develop neuropathy later in the disease course. This retrospective cohort study examined lipidomic profiles 10 years prior to type 2 diabetic neuropathy assessment. Participants comprised members of the Gila River Indian community with type 2 diabetes (n = 69) with available stored serum samples and neuropathy assessment 10 years later using the combined Michigan Neuropathy Screening Instrument (MNSI) examination and questionnaire scores. A combined MNSI index was calculated from examination and questionnaire scores. Serum lipids (435 species from 18 classes) were quantified by mass spectrometry. The cohort included 17 males and 52 females with a mean age of 45 years (SD = 9 years). Participants were stratified as with (high MNSI index score > 2.5407) versus without neuropathy (low MNSI index score ≤ 2.5407). Significantly decreased medium‐chain acylcarnitines and increased total free fatty acids, independent of chain length and saturation, in serum at baseline associated with incident peripheral neuropathy at follow‐up, that is, participants had high MNSI index scores, independent of covariates. Participants with neuropathy also had decreased phosphatidylcholines and increased lysophosphatidylcholines at baseline, independent of chain length and saturation. The abundance of other lipid classes did not differ significantly by neuropathy status. Abundance differences in circulating acylcarnitines, free fatty acids, phosphatidylcholines, and lysophosphatidylcholines 10 years prior to neuropathy assessment are associated with neuropathy status in type 2 diabetes.
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影响因子：
3.5
作者：
Basu Ball W;Neff JK;Gohil VM
通讯作者：
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影响因子：
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81.5
作者：
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Viswanathan, Vijay