Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass.
Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass.
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DOI：
10.1292/jvms.22-0191
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发表时间：
2022-08-01
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影响因子：
--
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中科院分区：
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--
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脂肪酸是哺乳动物身体的重要组成部分。它们通过不同的代谢途径，这取决于生理状态和炎症刺激。本研究采用液相色谱-串联质谱法（LC-MS/MS）对肝脏占位性病变犬尿液中的脂质代谢产物进行了综合分析。一些可能与疾病和/或全身炎症反应密切相关的脂质代谢产物的量存在显著差异，包括前列腺素E2和/或PGF 2 α代谢产物的增加。我们证明了我们分析尿液中脂质代谢物的方法有助于深入了解这种疾病。这些发现也可能有一个应用程序作为筛选测试或诊断工具，犬肝肿块。
Fatty acids are an essential component of mammalian bodies. They go through different metabolic pathways depending on physiological states and inflammatory stimuli. In this study, we conducted a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based comprehensive analysis of lipid metabolites in urine of canine patients with liver mass. There were significant differences in quantity of some lipid metabolites that may be closely associated with the disease and/or general inflammatory responses, including increased metabolites of prostaglandin E2 and/or PGF2α. We demonstrated that our approach of profiling lipid metabolites in the urine is useful in gaining insights into the disease. These findings may also have an application as a screening test or a diagnosis tool for canine liver mass.
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影响因子：
9.2
作者：
Ekambaram, Prasanna;Lambiv, Wanyu;Cazzolli, Rosanna;Ashton, Anthony W.;Honn, Kenneth V.
通讯作者：
Honn, Kenneth V.
影响因子：
2.9
作者：
MORROW, JD;PRAKASH, C;ROBERTS, LJ
通讯作者：
ROBERTS, LJ
影响因子：
2.9
作者：
FITZPATRICK, FA;WYNALDA, MA
通讯作者：
WYNALDA, MA
影响因子：
2.2
作者：
HANAI, T;HASHIMOTO, T;YURA, J
通讯作者：
YURA, J
影响因子：
8.8
作者：
Zimmerman, GA;McIntyre, TM;Stafforini, DM
通讯作者：
Stafforini, DM