Plasma cytokine concentrations associated with HIV/hepatitis C coinfection are related to attention, executive and psychomotor functioning.
Plasma cytokine concentrations associated with HIV/hepatitis C coinfection are related to attention, executive and psychomotor functioning.
复制标题
DOI：
10.1016/j.jneuroim.2010.11.006
复制
发表时间：
2011-04
影响因子：
3.3
通讯作者：
Tashima, Karen T.
中科院分区：
文献类型：
--
作者：
Cohen, Ronald A.;de la Monte, Suzanne;Gongvatana, Assawin;Ombao, Hernando;Gonzalez, Beverly;Devlin, Kathryn N.;Navia, Bradford;Tashima, Karen T.
关键词：
细胞因子紊乱与艾滋病毒感染者的脑功能障碍有关。过去的研究没有同时检查大量的细胞因子的措施和它们的关系，艾滋病毒相关的神经认知缺陷。我们假设，在HIV感染者中，注意力、执行力和精神功能的表现与血浆细胞因子浓度有关。通过xMAP多重珠阵列免疫测定法分析从30名HIV感染者和37名HIV血清阴性个体抽取的血浆样品，以确定13种细胞因子的浓度。评估了线索制作A/B、Stroop测试、字母编号排序、数字符号编码、符号搜索和凹槽钉板测试的性能。进行统计分析，以检查细胞因子浓度的组间差异，以及细胞因子和HIV临床变量与神经认知表现之间的关联。在13种细胞因子中的7种上发现了显著的HIV效应，主要是关于白细胞介素。HIV临床因素（CD 4和HIV RNA水平、病程、抗逆转录病毒治疗）和丙型肝炎状态与特定的血浆细胞因子浓度相关。神经认知测量与细胞因子浓度相关，在白细胞介素和IP-10中最一致。一般来说，细胞因子浓度是相对于其他临床因素的神经认知功能的最强预测因子之一，这加强了它们在检查HIV的神经病理过程中的潜在重要性。这些发现还指出了同时检查一组生物标志物的潜在价值。目前的结果表明，细胞因子之间可能存在复杂的关系[如何？]，这些关系不仅由艾滋病毒感染介导，而且还由抗逆转录病毒治疗和其他共病条件介导。
Cytokine disturbances have been linked to brain dysfunction among HIV-infected people. Past studies have not simultaneously examined a large set of cytokine measures and their relationships to HIV-associated neurocognitive deficits. We hypothesized that performance on measures of attention, and executive and psychomotor functions would be associated with plasma cytokine concentrations in HIV-infected individuals. Plasma samples drawn from 30 HIV-infected and 37 HIV seronegative individuals were analyzed via xMAP multiplexed bead array immunoassay to determine concentrations of thirteen cytokines. Performance on Trail Making A/B, Stroop Test, Letter Number Sequencing, Digit Symbol Coding, Symbol Search, and Grooved Pegboard tests was assessed. Statistical analyses were performed to examine group differences in cytokine concentrations, and associations between cytokine and HIV clinical variables and neurocognitive performance. Significant HIV effects were found on seven of the thirteen cytokines, primarily with respect to interleukins. HIV clinical factors (CD4 and HIV RNA levels, duration of illness, antiretroviral treatment) and hepatitis C status were associated with specific plasma cytokine concentrations. Neurocognitive measures were associated with cytokine concentrations, most consistently among the interleukins and IP-10. Generally, cytokine concentrations were among the strongest predictors of neurocognitive function relative to other clinical factors, which reinforces their potential importance in examining the neuropathological processes of HIV. The findings also point to the potential value of simultaneously examining a panel of biomarkers. The current results suggest that a complex relationship likely exists among cytokines [how?], and that these relationships are mediated not only by HIV infection, but also by antiretroviral treatment and other comorbid conditions.
影响因子：
8.6
作者：
Wang, Xinran;Ouyang, Yijian;Dai, Hongjie
通讯作者：
Dai, Hongjie