Microbiome maturation during a unique developmental window
Microbiome maturation during a unique developmental window
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微生物组在独特的发育窗口期间成熟
DOI：
10.1111/mec.15436
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发表时间：
2020
影响因子：
4.9
通讯作者：
Videvall, Elin
中科院分区：
文献类型：
--
作者：
Videvall, Elin
哺乳动物出生后不久，就被来自母亲和环境的大量微生物定植。模式生物的研究表明，在哺乳和断奶期间，后代肠道微生物组的结构和组成稳步成熟，多样性不断增加（Sommer & Bäckhed, 2013）。这一时期的微生物组组装对幼龄哺乳动物至关重要，因为它们获得的肠道微生物将有助于训练它们的免疫系统（Lathrop et al., 2011），并对它们的健康产生潜在的长期影响（Cox et al., 2014）。在本期《分子生态学》的一篇文章中，Stoffel等人（2020）研究了北象海豹（Mirounga angustirostris）在一个关键发育窗口期的肠道微生物群。生完孩子一个月后，海象妈妈就不再哺育幼崽，而是返回大海。因此，它们的幼崽从富含脂肪的牛奶中突然进入断奶后的禁食期，这段时间持续了大约两个月，而它们却留在了蚁群中。因此，这种特殊的生活史特征为作者提供了一个独特而令人兴奋的机会来评估野生海洋哺乳动物肠道微生物群发育的内在因素。
Shortly after birth, mammals are colonized by a multitude of microbes derived from the mother and the environment. Studies in model organisms have demonstrated that the structure and composition of the gut microbiome of offspring steadily mature with increasing diversity during nursing and weaning (Sommer & Bäckhed, 2013). This period of microbiome assembly is critical for young mammals because the gut microbes they acquire will help train their immune system (Lathrop et al., 2011) with potential long‐lasting effects on their health (Cox et al., 2014). In an article in this issue ofMolecular Ecology, Stoffel et al. (2020) investigated the gut microbiota of northern elephant seals (Mirounga angustirostris) during a key developmental window. A month after giving birth, elephant seal mothers stop nursing their pups and return to the sea. As a consequence, their pups go from a diet of milk rich in fat to abruptly enter a post weaning fasting period which lasts for about two months while they remain with the colony. This particular life‐history trait therefore offered the authors a unique and exciting opportunity to evaluate intrinsic factors contributing to gut microbiota development in a wild marine mammal.
北象海豹的发育：从断奶到营养独立的转变
影响因子：
2.3
作者：
Joanne Reiter;Nell Lee Stinson;B. L. Boeuf
通讯作者：
B. L. Boeuf
影响因子：
7.7
作者：
Tung J;Barreiro LB;Burns MB;Grenier JC;Lynch J;Grieneisen LE;Altmann J;Alberts SC;Blekhman R;Archie EA
通讯作者：
Archie EA