The effect of ethoxyquin on tissue peroxidation and immune status of single comb White Leghorn cockerels.
The effect of ethoxyquin on tissue peroxidation and immune status of single comb White Leghorn cockerels.
复制标题
乙氧基喹啉对单冠白来航公鸡组织过氧化和免疫状态的影响
DOI：
10.3382/ps.0751109
复制
发表时间：
1996
期刊：
影响因子：
4.4
通讯作者：
R. McGeachin
中科院分区：
文献类型：
--
作者：
C. Bailey;L. J. Srinivasan;R. McGeachin
研究了在饲料中添加乙氧喹对单头白来角鸡（SCWL）组织过氧化和免疫反应的影响。在第一个试验中，在基础饲粮中添加三种浓度的乙氧喹（0、500和1000 ppm），饲喂SCWL公鸡6周。通过测量肝脏、肾脏、心脏和脾脏中硫代巴比妥酸反应物质（TBARS）的浓度来评估组织过氧化。500ppm的饲粮乙氧喹显著降低了肝脏和脾脏组织中的TBARS浓度，而1000ppm的饲粮乙氧喹显著降低了肾脏中的TBARS浓度。在第二个试验中，在基础日粮中添加四种浓度的乙氧喹（0、125、500和1000 ppm），饲喂SCWL公鸡8周。利用血凝抑制（HI）和ELISA测定新城疫病毒抗体滴度，评估初级和次级免疫应答。原发性和继发性免疫反应的HI和ELISA滴度与对照组无显著差异。对体重、饲料转化率和器官重量的分析显示，不同处理之间没有统计学上的显著差异，尽管在第二个实验中，饲料中添加1,000 ppm的乙氧喹导致相对肝脏重量显著增加。
The responses to supplementing the diet of Single Comb White Leghorn (SCWL) cockerels with ethoxyquin were tested on two parameters: 1) tissue peroxidation and 2) immune response. In the first experiment, three concentrations of supplemental ethoxyquin (0, 500, and 1,000 ppm) were added to a basal diet and fed to SCWL cockerels for 6 wk. Tissue peroxidation was assessed by measuring the thiobarbituric acid reactive substances (TBARS) concentration in the liver, kidney, heart, and spleen. The TBARS concentration in response to 500 ppm dietary ethoxyquin was significantly lower in the liver and spleen tissues, whereas in the kidneys, 1,000 ppm ethoxyquin significantly lowered TBARS. In a second experiment, four concentrations of ethoxyquin (0, 125, 500, and 1,000 ppm) were added to a basal diet and fed to SCWL cockerels for 8 wk. The primary and secondary immune response were assessed by determining antibody titers to the Newcastle disease virus using hemagglutination inhibition (HI) and ELISA. The HI and ELISA titers for the primary and secondary immune response were not significantly different from the control. Analysis of body weight, feed conversion, and organ weight revealed no statistically significant differences between treatments, although in the second experiment the dietary treatment of 1,000 ppm ethoxyquin resulted in significantly higher relative liver weight.
维生素 E、β-胡萝卜素、辅酶 Q10 和硒的膳食补充剂可保护大鼠组织切片免受脂质过氧化的影响。
DOI：
10.1093/jn/120.1.97
发表时间：
1990
期刊：
The Journal of nutrition
影响因子：
--
作者：
Leibovitz,B;Hu,ML;Tappel,AL
通讯作者：
Tappel,AL
影响因子：
7.4
作者：
FRAGA, CG;LEIBOVITZ, BE;TAPPEL, AL
通讯作者：
TAPPEL, AL