PaO(2)/FiO(2) and IL-6 are risk factors of mortality for intensive care COVID-19 patients.
PaO(2)/FiO(2) and IL-6 are risk factors of mortality for intensive care COVID-19 patients.
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DOI：
10.1038/s41598-021-86676-3
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发表时间：
2021-04-01
影响因子：
4.6
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Gu Y;Wang D;Chen C;Lu W;Liu H;Lv T;Song Y;Zhang F
通过回顾性分析确定冠状病毒病19（COVID-19）患者入住重症监护室（ICU）的死亡风险因素。回顾性分析2020年2月10日至4月10日火神山医院ICU收治患者的人口统计学、临床、实验室和胸部影像学资料。连续变量和分类变量的比较分别采用Student t检验和卡方检验。采用Logistic回归模型分析死亡的危险因素。这项回顾性研究涉及123例患者，其中64例死亡，59例存活。其中，57人接受了白细胞介素-6（IL-6）检测（20人死亡，37人存活）。在所有入选患者中，氧合指数（PaO 2/FiO 2）被确定为独立风险因素（比值比[OR] = 0.96，95%置信区间[CI]：0.928-0.994，p = 0.021）。曲线下面积（AUC）为0.895（95% CI：0.826-0.943，p < 0.0001）。在检测IL-6的患者中，PaO 2/FiO 2（OR = 0.955，95%CI：0.915-0.996，p = 0.032）和IL-6（OR = 1.013，95%CI：1.001-1.025，p = 0.028）被确定为独立风险因素。IL-6的AUC为0.9（95% CI：0.791-0.964，p < 0.0001），PaO 2/FiO 2的AUC为0.865（95% CI：0.748-0.941，p < 0.0001）。PaO 2/FiO 2和IL-6可能作为预测需要重症监护的COVID-19患者死亡的独立风险因素。
To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t-test and Chi-square test were used to compare the continuous and categorical variables, respectively. The logistic regression model was employed to ascertain the risk factors of mortality. This retrospective study involved 123 patients, including 64 dead and 59 survivors. Among them, 57 people were tested for interleukin-6 (IL-6) (20 died and 37 survived). In all included patients, the oxygenation index (PaO2/FiO2) was identified as an independent risk factor (odd ratio [OR] = 0.96, 95% confidence interval [CI]: 0.928–0.994, p = 0.021). The area under the curve (AUC) was 0.895 (95% CI: 0.826–0.943, p < 0.0001). Among the patients tested for IL-6, the PaO2/FiO2 (OR = 0.955, 95%CI: 0.915–0.996, p = 0.032) and IL-6 (OR = 1.013, 95%CI: 1.001–1.025, p = 0.028) were identified as independent risk factors. The AUC was 0.9 (95% CI: 0.791–0.964, p < 0.0001) for IL-6 and 0.865 (95% CI: 0.748–0.941, p < 0.0001) for PaO2/FiO2. PaO2/FiO2 and IL-6 could potentially serve as independent risk factors for predicting death in COVID-19 patients requiring intensive care.
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影响因子：
168.9
作者：
Pathan, N;Hemingway, CA;Levin, M
通讯作者：
Levin, M
影响因子：
6.2
作者：
Nazha B;Goyal S;Chen Z;Engelhart A;Carlisle JW;Beardslee TJ;Gill H;Odikadze L;Liu Y;Mishra MK;Ramalingam SS;Owonikoko TK
通讯作者：
Owonikoko TK
DOI：
10.1038/nrclinonc.2018.8
发表时间：
2018-04
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Johnson DE;O'Keefe RA;Grandis JR
通讯作者：
Grandis JR
DOI：
10.1634/theoncologist.2018-0028
发表时间：
2018-08
期刊：
The oncologist
影响因子：
--
作者：
Le RQ;Li L;Yuan W;Shord SS;Nie L;Habtemariam BA;Przepiorka D;Farrell AT;Pazdur R
通讯作者：
Pazdur R
影响因子：
168.9
作者：
Chen, Nanshan;Zhou, Min;Zhang, Li
通讯作者：
Zhang, Li