Immunological alterations mediated by adenosine during host-microbial interactions.
Immunological alterations mediated by adenosine during host-microbial interactions.
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DOI：
10.1007/s12026-011-8207-0
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发表时间：
2011-05
影响因子：
4.4
通讯作者：
Glomski, Ian J.
中科院分区：
文献类型：
--
作者：
Drygiannakis, Ioannis;Ernst, Peter B.;Lowe, David;Glomski, Ian J.
腺苷在炎症和缺血中积累，但它不仅仅是ATP分解代谢的最终产物。腺苷通过不同的受体传递信号，具有不同的细胞特异性胞浆通路，现在被认为是调节免疫系统的可诱导开关。通过A2AAR的作用，腺苷塑造T细胞的功能，主要是通过向效应器Th细胞和自然杀伤细胞(NK细胞)传递抗炎基调。相反，A2AAR和A2BAR都由抗原提呈细胞(APC)表达，APC已被证明调节先天反应和向获得性免疫的转变。也有新的证据表明，腺苷的产生是允许一些病原体和肿瘤逃避宿主防御的一种机制。这篇综述讨论了腺苷的免疫调节功能以及它在调节宿主-微生物相互作用中可能具有的一些相互作用。
Adenosine accumulates in inflammation and ischemia but it is more than an end-product of ATP catabolism. Signaling through different receptors with distinct, cell-specific cytoplasmic pathways, adenosine is now recognized as an inducible switch that regulates the immune system. By acting through the A2AAR, adenosine shapes T cell function, largely by conferring an anti-inflammatory tone on effector Th cells (Teff) and natural killer (NK)T cells. In contrast, both the A2AAR and A2BAR are expressed by antigen-presenting cells (APC) which have been shown to regulate innate responses and the transition to adaptive immunity. There is also emerging evidence that adenosine production is one mechanism that allows some pathogens as well as neoplasms to evade host defenses. This review discusses the immunoregulatory functions of adenosine and some of the interactions it may have in regulating host–microbial interactions.
影响因子：
8.6
作者：
Wang, Xinran;Ouyang, Yijian;Dai, Hongjie
通讯作者：
Dai, Hongjie