Association between risk of preeclampsia and maternal plasma trimethylamine-N-oxide in second trimester and at the time of delivery
Association between risk of preeclampsia and maternal plasma trimethylamine-N-oxide in second trimester and at the time of delivery
复制标题
先兆子痫风险与妊娠中期和分娩时母体血浆三甲胺-N-氧化物之间的关联
DOI：
10.1186/s12884-020-02997-7
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发表时间：
2020-03
影响因子：
3.1
通讯作者：
Lei Jun
中科院分区：
文献类型：
--
作者：
Huang Xin;Li Zuodong;Gao Zhou;Wang Dapeng;Li Xiaohui;Li Ying;Mi Chunmei;Lei Jun
关于妊娠期间微生物依赖代谢物三甲胺- n -氧化物（TMAO）与子痫前期（PE）风险之间关系的数据有限。因此，我们于2017年9月至2018年12月进行了一项前瞻性巢式病例对照研究，以研究妊娠期间血浆TMAO测量与PE风险之间的关系。共纳入17例早发性PE （EOPE）患者、49例晚发性PE （LOPE）患者和198例健康对照。于妊娠15-23周及分娩时采集血样。采用Logistic回归模型评估TMAO与PE、EOPE、LOPE、轻度PE和重度PE风险的比值比（OR）和95%置信区间（CI）。结果所有被试在妊娠中期（T2）和分娩时（TD）的平均TMAO水平分别为90.39 μg/m3（标准差(SD) =45.91）和175.01 μg/m3（SD = 160.97）。两期TMAO无明显spearman相关性（p < 0.05）。T2 TMAO与PE或任何PE亚型的风险无显著相关性（p < 0.05）。然而，TMAO与PE、EOPE和严重PE的风险显著相关（校正OR和95%CI分别为1.24（1.09,1.40）、1.62（1.29,2.03）和1.41(1.17,1.70)）。结论本研究发现血浆TMAO水平在妊娠期间会发生变化。TMAO在PE发展中的主要作用可能是在加速过程中，而不是在启动过程中。
BackgroundThe data on the association between the microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) during pregnancy and risk of preeclampsia (PE) is limited.MethodsWe, therefore, conducted a prospective nested case control study during Sep 2017 to Dec 2018 to examine the association between plasma TMAO measured during pregnancy and the risk of PE. Total of 17 patients diagnosed with early onset PE (EOPE), 49 with late onset PE (LOPE) and 198 healthy controls were enrolled. Blood samples were collected at 15–23 weeks gestation and time at delivery. The Logistic regression model was used to assess the odds ratio (OR) and 95% confidence interval (CI) for TMAO and risk of PE, EOPE, LOPE, mild PE, and severe PE.ResultsWe found that the mean TMAO levels of overall subjects in the second trimester (T2) and at the time of delivery (TD) were 90.39 μg/m3(standard deviation (SD) =45.91) and 175.01 μg/m3(SD = 160.97), respectively. No significant spearman correlation was found between the TMAO in those two periods (p> 0.05). T2 TMAO was not significantly associated with risk of PE or risk of any PE subtypes (p> 0.05). However, TD TMAO was significant associated with risk of PE, EOPE and severe PE (adjusted OR and 95%CI were 1.24(1.09, 1.40), 1.62(1.29, 2.03), and 1.41(1.17, 1.70)) per 50 μg/m3increment, respectively).ConclusionOur study found that plasma TMAO level would alter over the course of pregnancy. The major role of TMAO in PE development might be in the accelerating process not in the initiation.
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影响因子：
5.3
作者：
通讯作者：
--
DOI：
10.1056/nejmoa1109400
发表时间：
2013-04-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tang WH;Wang Z;Levison BS;Koeth RA;Britt EB;Fu X;Wu Y;Hazen SL
通讯作者：
Hazen SL
影响因子：
64.8
作者：
A. Lusis
通讯作者：
A. Lusis
影响因子：
5.6
作者：
Mugo, M;Govindarajan, G;McFarlane, SI
通讯作者：
McFarlane, SI
影响因子：
4.7
作者：
Cucó, G;Fernández-Ballart, J;Arija, V
通讯作者：
Arija, V