Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats.
Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats.
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DOI：
10.1007/s00213-010-2132-0
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发表时间：
2011-05
影响因子：
3.4
通讯作者：
Glick, Stanley D.
中科院分区：
文献类型：
--
作者：
McCallum, Sarah E.;Taraschenko, Olga D.;Hathaway, Ethan R.;Vincent, Melanie Y.;Glick, Stanley D.
18-Methoxycoronaridine (18-MC) 是一种 α3β4 烟碱受体的选择性拮抗剂，先前已在大鼠中显示，可以减少几种滥用药物的自我给药，减少对蔗糖的操作反应，并预防蔗糖诱导的肥胖的发生。越来越明显的是，调节药物奖励和食物摄入的系统之间存在显着的重叠，因此，我们研究了 18-MC 是否可能调节生长素释放肽的作用，生长素释放肽是最近与进食和药物奖励有关的几种促食欲肽之一。在雌性 Sprague-Dawley 大鼠中，我们确定急性 18-MC 治疗是否会减少 ghrelin 诱导的蔗糖摄入量增加和 ghrelin 引起的累积多巴胺水平增加。在给予 ghrelin（1 µg，侧脑室）之前使用 18-MC（20 mg/kg，腹腔注射）进行预处理，在两瓶开放获取范例中阻止了 ghrelin 诱导的蔗糖摄入量增加（5%）。使用体内微透析，18-MC（20 和 40 mg/kg）可防止 ghrelin（2 µg，腹侧被盖区）诱导的伏隔核细胞外多巴胺增加。 18-MC 对生长素释放肽治疗的大鼠的脂肪沉积或葡萄糖、甘油三酯和胆固醇的血清水平没有影响。目前的结果表明，18-MC 对美味食物消费发挥作用的一种潜在机制是通过调节生长素释放肽的作用。
18-Methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been previously shown, in rats, to reduce the self-administration of several drugs of abuse, reduce operant responding for sucrose, and prevent the development of sucrose-induced obesity. It has become increasingly apparent that there is a significant overlap between the systems regulating drug reward and food intake, therefore, we investigated whether 18-MC might modulate the effects of ghrelin, one of several orexigenic peptides recently implicated in both feeding and drug reward. In female Sprague–Dawley rats, we determined whether acute 18-MC treatment would reduce both ghrelin-induced increases in sucrose intake and ghrelin-elicited increases in accumbal dopamine levels. Pretreatment with 18-MC (20 mg/kg, i.p.), given prior to the administration of ghrelin (1 µg, lateral ventricle), blocked ghrelin-induced increases in sucrose (5%) intake in a two-bottle open access paradigm. Using in vivo microdialysis, 18-MC (both 20 and 40 mg/kg) prevented ghrelin (2 µg, intraventral tegmental area)-induced increases in extracellular dopamine in the nucleus accumbens. 18-MC had no effect on deposition of fat or on serum levels of glucose, triglycerides, and cholesterol in ghrelin-treated rats. The present results suggest that one potential mechanism by which 18-MC exerts its effects on palatable food consumption is via modulation of ghrelin’s effects.
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影响因子：
5
作者：
Glick, SD;Maisonneuve, IM;Fleck, MW
通讯作者：
Fleck, MW
影响因子：
5.6
作者：
Jerlhag, Elisabet;Egecioglu, Emil;Engel, Jorgen A.
通讯作者：
Engel, Jorgen A.
DOI：
10.1523/jneurosci.3890-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrews ZB;Erion D;Beiler R;Liu ZW;Abizaid A;Zigman J;Elsworth JD;Savitt JM;DiMarchi R;Tschoep M;Roth RH;Gao XB;Horvath TL
通讯作者：
Horvath TL
影响因子：
15.9
作者：
Abizaid, Alfonso;Liu, Zhong-Wu;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
DOI：
10.1016/s0169-328x(97)00071-5
发表时间：
1997-08-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Guan, XM;Yu, H;Howard, AD
通讯作者：
Howard, AD