Disrupted brain metabolic connectivity in a 6-OHDA-induced mouse model of Parkinson's disease examined using persistent homology-based analysis.
Disrupted brain metabolic connectivity in a 6-OHDA-induced mouse model of Parkinson's disease examined using persistent homology-based analysis.
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DOI：
10.1038/srep33875
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发表时间：
2016-09-21
影响因子：
4.6
通讯作者：
Lee DS
中科院分区：
文献类型：
--
作者：
Im HJ;Hahm J;Kang H;Choi H;Lee H;Hwang do W;Kim EE;Chung JK;Lee DS
帕金森病（PD）的运动障碍是由多巴胺能神经元的变性和随后的皮质-纹状体-丘脑回路连接中断引起的。本研究使用18 F-氟脱氧葡萄糖正电子发射断层扫描（FDG PET）评价了6-羟基多巴胺（6-OHDA）诱导的PD小鼠模型中的脑代谢连接。14只PD模型小鼠和10只对照小鼠用于分析。FDG PET结果的体素t检验显示PD组和对照组之间没有显著的区域代谢差异。然而，PD组显示右侧尾壳核与左侧尾壳核和右侧视皮层之间的相关性较低。基于无阈值持续同源框架的进一步网络分析显示，PD组的大脑网络被全面破坏，特别是在右侧听觉皮层和双侧皮层结构与左侧尾壳核之间。总之，局部葡萄糖代谢的PD保存，但皮质-纹状体-丘脑回路的代谢连接在PD中被全面损害。
Movement impairments in Parkinson’s disease (PD) are caused by the degeneration of dopaminergic neurons and the consequent disruption of connectivity in the cortico-striatal-thalamic loop. This study evaluated brain metabolic connectivity in a 6-Hydroxydopamine (6-OHDA)-induced mouse model of PD using 18F-fluorodeoxy glucose positron emission tomography (FDG PET). Fourteen PD-model mice and ten control mice were used for the analysis. Voxel-wise t-tests on FDG PET results yielded no significant regional metabolic differences between the PD and control groups. However, the PD group showed lower correlations between the right caudoputamen and the left caudoputamen and right visual cortex. Further network analyses based on the threshold-free persistent homology framework revealed that brain networks were globally disrupted in the PD group, especially between the right auditory cortex and bilateral cortical structures and the left caudoputamen. In conclusion, regional glucose metabolism of PD was preserved, but the metabolic connectivity of the cortico-striatal-thalamic loop was globally impaired in PD.
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影响因子：
0.5
作者：
KAMADA, T;KAWAI, S
通讯作者：
KAWAI, S
影响因子：
4.8
作者：
Baik, KyoungWon;Cha, Jungho;Lee, Phil Hyu
通讯作者：
Lee, Phil Hyu
影响因子：
14.5
作者：
Hacker, Carl D.;Perlmutter, Joel S.;Snyder, Abraham Z.
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影响因子：
6.3
作者：
EIDELBERG, D;MOELLER, JR;FAHN, S
通讯作者：
FAHN, S
DOI：
10.1007/s00259-008-0808-z
发表时间：
2008-09-01
影响因子：
9.1
作者：
Lee, Dong Soo;Kang, Hyejin;Lee, Myung Chul
通讯作者：
Lee, Myung Chul