Parabrachial complex links pain transmission to descending pain modulation.
Parabrachial complex links pain transmission to descending pain modulation.
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DOI：
10.1097/j.pain.0000000000000688
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发表时间：
2016-12
期刊：
影响因子：
7.4
通讯作者：
Heinricher MM
中科院分区：
文献类型：
--
作者：
Roeder Z;Chen Q;Davis S;Carlson JD;Tupone D;Heinricher MM
延髓头端腹内侧区（RVM）在疼痛调制中具有良好的记录作用，并通过两种不同类型的神经元（OFF细胞和ON细胞）介导产生抗伤害性和促伤害性影响。OFF-细胞由响应于伤害性输入的放电的突然暂停来定义，而ON-细胞的特征在于活动的“爆发”。虽然这些反射相关的ON和OFF细胞放电的变化是至关重要的，他们的疼痛调节功能，介导这些反应的途径尚未确定。本实验旨在验证伤害性传入RVM是通过臂旁复合体（PB）传递的假说。在电生理学研究中，在轻度麻醉的雄性大鼠的RVM中记录了利多卡因或蝇蕈醇注入PB之前和之后的ON和OFF细胞。ON-细胞爆发和OFF-细胞暂停引起的有害热或机械探测基本上衰减的外侧，但不是内侧，臂旁区的失活。逆行追踪显示投射至RVM的神经元散在分布于PB。这些神经元中很少有降钙素基因相关肽（CGRP）的表达，这表明从PB的RVM的投射是不同的杏仁核。这些数据表明，“自下而上”的伤害性驱动RVM疼痛调节神经元的实质性组成部分是通过臂旁复合体中继。虽然臂旁复合体被认为是上行伤害性信息的重要中继，但其与RVM的功能连接允许脊髓臂旁通路作为复发回路的一部分访问下行控制系统。
The rostral ventromedial medulla (RVM) has a well-documented role in pain modulation, and exerts anti-nociceptive and pro-nociceptive influences mediated by two distinct classes of neurons, OFF-cells and ON-cells. OFF-cells are defined by a sudden pause in firing in response to nociceptive inputs, whereas ON-cells are characterized by a “burst” of activity. Although these reflex-related changes in ON- and OFF-cell firing are critical to their pain-modulating function, the pathways mediating these responses have not been identified. The present experiments were designed to test the hypothesis that nociceptive input to the RVM is relayed through the parabrachial complex (PB). In electrophysiological studies, ON- and OFF-cells were recorded in the RVM of lightly anesthetized male rats before and after an infusion of lidocaine or muscimol into PB. The ON-cell burst and OFF-cell pause evoked by noxious heat or mechanical probing were substantially attenuated by inactivation of the lateral, but not medial, parabrachial area. Retrograde tracing studies showed that neurons projecting to the RVM were scattered throughout PB. Few of these neurons expressed calcitonin gene-related peptide (CGRP), suggesting that the RVM projection from PB is distinct from that to the amygdala. These data show that a substantial component of “bottom-up” nociceptive drive to RVM pain-modulating neurons is relayed through the parabrachial complex. While the parabrachial complex is well-known as an important relay for ascending nociceptive information, its functional connection with the RVM allows the spinoparabrachial pathway to access descending control systems as part of a recurrent circuit.
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影响因子：
5.3
作者：
Bourgeais, L;Monconduit, L;Bernard, JF
通讯作者：
Bernard, JF
影响因子：
5.3
作者：
Carlson, Jonathan D.;Maire, Jennifer J.;Heinricher, Mary M.
通讯作者：
Heinricher, Mary M.
DOI：
10.1098/rstb.1985.0037
发表时间：
1985-01-01
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
FIELDS, HL;HEINRICHER, MM
通讯作者：
HEINRICHER, MM
影响因子：
11.2
作者：
Edelmayer, Rebecca M.;Vanderah, Todd W.;Majuta, Lisa;Zhang, En-Tan;Fioravanti, Beatriz;De Felice, Milena;Chichorro, Juliana G.;Ossipov, Michael H.;King, Tamara;Lai, Josephine;Kori, Shashi H.;Nelsen, Andrew C.;Cannon, Keri E.;Heinricher, Mary M.;Porreca, Frank
通讯作者：
Porreca, Frank
影响因子：
64.5
作者：
Han S;Soleiman MT;Soden ME;Zweifel LS;Palmiter RD
通讯作者：
Palmiter RD