Composite hydrogels of polyacrylamide and crosslinked pH-responsive micrometer-sized hollow particles.
Composite hydrogels of polyacrylamide and crosslinked pH-responsive micrometer-sized hollow particles.
复制标题
聚丙烯酰胺和交联 pH 响应微米尺寸空心颗粒的复合水凝胶。
作者：
Pafiti K
虽然水凝胶和中空颗粒在文献中继续吸引很多关注，但含有中空颗粒的水凝胶复合材料的实例很少。在这里，我们研究复合聚丙烯酰胺（PAAm）水凝胶含有微米级的pH值响应壳交联的空心粒子（简称HPXL）的基础上聚（甲基丙烯酸甲酯-共-甲基丙烯酸）功能化与甲基丙烯酸缩水甘油酯（GMA）。使用我们的可缩放乳液模板方法制备HPXL颗粒，并且发现包含GMA促进球形中空颗粒的形成。来自GMA的侧链乙烯基使得能够在形成PAAm/HPXL复合凝胶之前制备壳交联的中空颗粒。利用光学显微镜、激光共聚焦扫描显微镜和扫描电子显微镜对粒子和复合凝胶的形貌进行了研究。复合凝胶的动态流变学测量表明，模量随HPXL浓度的变化可以描述的逾渗模型与HPXL逾渗阈值浓度为4.4重量%和标度指数为2.6。复合凝胶是pH响应性的，并且在pH 4.0至8.0的范围内基本上保持其机械性能。由于复合凝胶具有可调的机械性能（模量值高达530 kPa）和pH响应性，它们是未来伤口愈合或膜应用的潜在候选者。
Whilst hydrogels and hollow particles both continue to attract much attention in the literature there are few examples of hydrogel composites containing hollow particles. Here, we study composite polyacrylamide (PAAm) hydrogels containing micrometer-sized pH-responsive shell-crosslinked hollow particles (abbreviated as HPXL) based on poly(methylmethacrylate-co-methacrylic acid) functionalised with glycidyl methacrylate (GMA). The HPXL particles were prepared using our scaleable emulsion template method and inclusion of GMA was found to promote spherical hollow particle formation. The pendant vinyl groups from GMA enabled shell-crosslinked hollow particles to be prepared prior to formation of the PAAm/HPXL composite gels. The morphologies of the particles and composite gels were studied by optical microscopy, confocal laser scanning microscopy and scanning electron microscopy. Dynamic rheology measurements for the composite gels showed that the modulus variation with HPXL concentration could be described by a percolation model with a HPXL percolation threshold concentration of 4.4 wt% and a scaling exponent of 2.6. The composite gels were pH-responsive and largely maintained their mechanical properties over the pH range 4.0 to 8.0. Because the composite gels had tuneable mechanical properties (with modulus values up to 530 kPa) and were pH-responsive they are potential candidates for future wound healing or membrane applications.
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DOI：
10.1007/978-3-642-00865-8_23
发表时间：
2009
期刊：
Progress in colloid and polymer science
影响因子：
--
作者：
T. Mitsumata;Y. Kosugi;S. Ouchi
通讯作者：
T. Mitsumata;Y. Kosugi;S. Ouchi
影响因子：
5.5
作者：
Miyazaki, Sho;Karino, Takeshi;Shibayama, Mitsuhiro
通讯作者：
Shibayama, Mitsuhiro
影响因子：
17.1
作者：
Shin, Su Ryon;Jung, Sung Mi;Zalabany, Momen;Kim, Keekyoung;Zorlutuna, Pinar;Kim, Sang Bok;Nikkhah, Mehdi;Khabiry, Masoud;Azize, Mohamed;Kong, Jing;Wan, Kai-tak;Palacios, Tomas;Dokmeci, Mehmet R.;Bae, Hojae;Tang, Xiaowu (Shirley);Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
影响因子：
3.3
作者：
Tanaka, Y;Kuwabara, R;Osada, Y
通讯作者：
Osada, Y
影响因子：
5.5
作者：
Haraguchi, K;Farnworth, R;Takehisa, T
通讯作者：
Takehisa, T