Two-Year Quality of Life Outcomes After Robotic-Assisted Minimally Invasive and Open Esophagectomy.
Two-Year Quality of Life Outcomes After Robotic-Assisted Minimally Invasive and Open Esophagectomy.
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DOI：
10.1016/j.athoracsur.2020.09.027
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发表时间：
2021-09
影响因子：
4.6
通讯作者：
Bott, Matthew J.
中科院分区：
文献类型：
--
作者：
Vimolratana, Marc;Sarkaria, Inderpal S.;Goldman, Debra A.;Rizk, Nabil P.;Tan, Kay See;Bains, Manjit S.;Adusumilli, Prasad S.;Sihag, Smita;Isbell, James M.;Huang, James;Park, Bernard J.;Molena, Daniela;Rusch, Valerie W.;Jones, David R.;Bott, Matthew J.
机器人辅助微创食道切除术(RAMIE)是开放食道切除术(OE)的一种安全选择。然而，这些手术后生活质量(QOL)的差异仍不清楚。我们之前报道了苎麻和OE后的短期生活质量结果，并在这里描述了我们两年的随访结果。我们在一家机构进行了一项前瞻性的非随机试验，研究对象是食道癌患者，他们接受了经胸切除手术。主要结果是患者报告的生活质量，由癌症治疗功能评估-食道(FACT-E)衡量，疼痛由简短疼痛问卷(BPI)衡量。使用广义线性模型来评估生活质量结果和手术队列之间的关系。使用错误发现率校正来调整每个模型中的P值(p-adj)。总共有170例患者接受了食道切除术(包括106例OE和苎麻)。两组在任何测量的临床病理变量上没有显著差异。在控制协变量后，苎麻队列中的FACT-E得分高于OE队列中的得分(参数估计[PE]，6.13；p-adj=0.051)。苎麻与食道癌因子分(PE，2.72；p-adj=0.022)和情绪幸福感(PE，1.25；p-adj=0.016)得分相关。麻麻组的疼痛严重程度评分低于OE组(PE，−=0.005)，但疼痛干预评分在两组间无显著差异(P-ADJ=0.11)。在两年的随访中，与OE相比，Ramie组患者报告的生活质量得到改善，包括食道症状和情绪健康，并减少了疼痛。
Robotic-assisted minimally invasive esophagectomy (RAMIE) is a safe alternative to open esophagectomy (OE). However, differences in quality of life (QOL) after these procedures remain unclear. We previously reported on short-term QOL outcomes after RAMIE and OE and describe here our results from two years of follow-up. We conducted a prospective, nonrandomized trial of patients with esophageal cancer undergoing transthoracic resection via RAMIE or OE at a single institution. The primary outcomes were patient-reported QOL, measured by the Functional Assessment of Cancer Therapy–Esophageal (FACT-E), and pain, measured by the Brief Pain Inventory (BPI). Generalized linear models were used to assess the relationship between QOL outcomes and surgery cohort. P values were adjusted (p-adj) within each model using the false discovery rate correction. In total, 170 patients underwent esophagectomy (106 OE and 64 RAMIE). The groups did not differ significantly by any measured clinicopathologic variables. After covariates were controlled for, FACT-E scores were higher in the RAMIE cohort than in the OE cohort (parameter estimate [PE], 6.13; p-adj=0.051). RAMIE was associated with higher esophageal cancer subscale (PE, 2.72; p-adj=0.022) and emotional well-being (PE, 1.25; p-adj=0.016) scores. BPI pain severity scores were lower in the RAMIE cohort than in the OE cohort (PE, −0.56; p-adj=0.005), but pain interference scores did not differ significantly between groups (p-adj=0.11). During 2 years of follow-up, RAMIE was associated with improved patient-reported QOL, including esophageal symptoms and emotional well-being, and decreased pain, compared with OE.
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影响因子：
6.2
作者：
Lagergren, Pernilla;Avery, Kerry N. L.;Blazeby, Jane M.
通讯作者：
Blazeby, Jane M.
影响因子：
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Luketich JD;Pennathur A;Franchetti Y;Catalano PJ;Swanson S;Sugarbaker DJ;De Hoyos A;Maddaus MA;Nguyen NT;Benson AB;Fernando HC
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van der Peet, Donald L.
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作者：
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通讯作者：
Piessen, Guillaume
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3.7
作者：
Parameswaran, R.;McNair, A.;Blazeby, J. M.
通讯作者：
Blazeby, J. M.