Autonomous wearable sweat rate monitoring based on digitized microbubble detection.
Autonomous wearable sweat rate monitoring based on digitized microbubble detection.
复制标题
基于数字化微泡检测的自主可穿戴出汗率监测。
DOI：
10.1039/d2lc00670g
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发表时间：
2022-11-08
期刊：
影响因子：
6.1
通讯作者：
Emaminejad, Sam
中科院分区：
文献类型：
--
作者：
Lin, Haison G.;Yu, Wenzhuo;De Dios Suarez, Jorge Emiliano;Athavan, Harish;Wang, Yibo;Yeung, Christopher;Lin, Shuyu;Sankararaman, Sriram;Milla, Carlos;Emaminejad, Sam
可穿戴生物分析微系统的进步使得能够通过探测汗液来实现对生理相关指标的昼夜和（半）连续监测。为了提供这些读数的不失真和生理上有意义的解释，跟踪汗液分泌速率是必不可少的，因为它允许校准生物标志物读数对汗液分泌的变化，并推断身体的水合/电解质稳态状态。为了实现具有固有高信噪比汗液速率感测能力的自主可穿戴解决方案，在这里，我们设计了一种数字化微泡检测机制-由具有紧凑占地面积的混合微流体/电子系统提供。这种机制是基于间歇产生微升规模的气泡通过电解和瞬时测量的飞行时间（因此，速度）通过阻抗传感。以这种方式，我们克服了先前提出的汗液速率感测模态的局限性，所述汗液速率感测模态固有地易受非目标分泌特性（pH、电导率和温度）的影响，受体积的约束，或者缺乏用于自主身体上操作的系统集成。通过在人体受试者试验中部署我们的解决方案，我们验证了我们的解决方案在无缝监测运动和离子电渗诱导的汗液分泌概况方面的实用性。设计了一种由混合微流体/电子系统提供的数字化微泡检测机制，用于自主可穿戴高信噪比汗液速率监测。
Advancements in wearable bioanalytical microsystems have enabled diurnal and (semi)continuous monitoring of physiologically-relevant indices that are accessible through probing sweat. To deliver an undistorted and physiologically-meaningful interpretation of these readings, tracking the sweat secretion rate is essential, because it allows for calibrating the biomarker readings against variations in sweat secretion and inferring the body’s hydration/electrolyte homeostasis status. To realize an autonomous wearable solution with intrinsically high signal-to-noise ratio sweat rate sensing capabilities, here, we devise a digitized microbubble detection mechanism—delivered by a hybrid microfluidic/electronic system with a compact footprint. This mechanism is based on the intermittent generation of microliter-scale bubbles via electrolysis and the instantaneous measurement of their time-of-flight (and thus, velocity) via impedimetric sensing. In this way, we overcome the limitations of previously proposed sweat rate sensing modalities that are inherently susceptible to non-targeted secretion characteristics (pH, conductivity, and temperature), constrained by volume, or lack system integration for autonomous on-body operation. By deploying our solution in human subject trials, we validate the utility of our solution for seamless monitoring of exercise- and iontophoretically-induced sweat secretion profiles. A digitized microbubble detection mechanism delivered by a hybrid microfluidic/electronic system is devised for autonomous wearable high signal-to-noise ratio sweat rate monitoring.
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