Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
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DOI：
10.1016/j.devcel.2009.05.012
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发表时间：
2009-07
影响因子：
11.8
通讯作者：
Wells, James M.
中科院分区：
文献类型：
--
作者：
Spence, Jason R.;Lange, Alex W.;Lin, Suh-Chin J.;Kaestner, Klaus H.;Lowy, Andrew M.;Kim, Injune;Whitsett, Jeffrey A.;Wells, James M.
腹侧胰腺、胆管系统和肝脏起源于后腹侧前肠，但这些器官谱系分离的细胞内在途径尚不清楚。在这里，我们表明肝外胆管系统与腹侧胰腺有共同的起源，而不是先前认为的肝脏。这些胰胆祖细胞在E8.5处共表达转录因子Pdx1和Sox17，并将它们分离到Pdx1+腹侧胰腺和Sox17+胆管原基。Sox17基因E8.5位缺失导致肝芽和总胆管中胆管结构和异位胰腺组织的丧失，而Sox17过表达抑制胰腺发育，促进Pdx1+结构域中异位胆管样组织的形成。将Sox17+胆汁祖细胞限制在肠道腹侧需要缺口效应因子Hes1。我们的结果强调了Sox17和Hes1在前肠腹侧谱系的图案化和形态发生分离中的作用。
The ventral pancreas, biliary system and liver arise from the posterior ventral foregut, but the cell-intrinsic pathway by which these organ lineages are separated is not known. Here we show that the extrahepatobiliary system shares a common origin with the ventral pancreas and not the liver, as previously thought. These pancreatobiliary progenitor cells coexpress the transcription factors Pdx1 and Sox17 at e8.5 and their segregation into a Pdx1+ ventral pancreas and a Sox17+ biliary primordium is Sox17-dependant. Deletion of Sox17 at e8.5 results in the loss of biliary structures and ectopic pancreatic tissue in the liver bud and common duct, while Sox17 overexpression suppresses pancreas development and promotes ectopic biliary-like tissue throughout the Pdx1+ domain. Restricting Sox17+ biliary progenitor cells to the ventral region of the gut requires the notch effector Hes1. Our results highlight the role of Sox17 and Hes1 in patterning and morphogenetic segregation of ventral foregut lineages.
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影响因子：
11.8
作者：
Chung, Won-Suk;Shin, Chong Hyun;Stainier, Didier Y. R.
通讯作者：
Stainier, Didier Y. R.
影响因子：
4
作者：
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通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
Leach, SD
影响因子：
64.8
作者：
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通讯作者：
EDLUND, H
影响因子：
4.8
作者：
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通讯作者：
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