Complexing Receptor Pharmacology
Complexing Receptor Pharmacology
复制标题
复合受体药理学
DOI：
--
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
A. Christopoulos
中科院分区：
文献类型：
--
作者：
P. Sexton;M. Morfis;N. Tilakaratne;D. Hay;M. Udawela;G. Christopoulos;A. Christopoulos
摘要：bgp蛋白偶联受体（gpcr）家族中最具特征的亚群包括肽激素受体，如分泌素、降钙素（CT）、胰高血糖素和血管活性肠肽（VIP）。最近的数据表明，许多这些受体可以与一个新的GPCR附属蛋白家族相互作用，称为受体活性修饰蛋白（RAMPs）。RAMP与受体的相互作用可导致多种作用，包括受体蛋白到细胞表面的伴随，如降钙素受体样受体（CLR）和新受体表型的产生。RAMP与CLR和相关的CT受体异二聚化是形成特定的CT基因相关肽、肾上腺髓质素（AM）或淀粉酶受体所必需的。最近的研究表明，异源二聚体中存在的特异性RAMP可能调节其他功能，如受体内化和再循环，以及下游信号通路的激活强度。在这篇文章中，我们回顾了RAMP与B家族gpcr相互作用的后果的当前知识状态。
Abstract: The most well‐characterized subgroup of family B G protein–coupledreceptors (GPCRs) comprises receptors for peptide hormones, such as secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP). Recent data suggest that many of these receptors can interact with a novel family of GPCR accessory proteins termed receptor activity modifying proteins (RAMPs). RAMP interaction with receptors can lead to a variety of actions that include chaperoning of the receptor protein to the cell surface as is the case for the calcitonin receptor‐like receptor (CLR) and the generation of novel receptor phenotypes. RAMP heterodimerization with the CLR and related CT receptor is required for the formation of specific CT gene‐related peptide, adrenomedullin (AM) or amylin receptors. More recent work has revealed that the specific RAMP present in a heterodimer may modulate other functions such as receptor internalization and recycling and also the strength of activation of downstream signaling pathways. In this article we review our current state of knowledge of the consequence of RAMP interaction with family B GPCRs.
影响因子：
3.9
作者：
M. A. Prado;B. Evans-Bain;I. Dickerson
通讯作者：
M. A. Prado;B. Evans-Bain;I. Dickerson
DOI：
10.1073/pnas.93.8.3455
发表时间：
1996-04-16
影响因子：
11.1
作者：
Luebke, AE;Dahl, GP;Dickerson, IM
通讯作者：
Dickerson, IM