Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.
Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.
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DOI：
10.1016/j.mce.2011.11.002
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发表时间：
2012-06-05
影响因子：
4.1
通讯作者：
Oh, Jeong Su
中科院分区：
文献类型：
--
作者：
Conti, Marco;Hsieh, Minnie;Zamah, A. Musa;Oh, Jeong Su
在围排卵期间，促性腺激素 LH 会引发卵泡体细胞和生殖细胞室的重大变化。卵母细胞完成减数分裂细胞周期，成为受精卵，卵泡体细胞室中基因表达和分泌发生巨大变化，为卵泡破裂和卵母细胞释放做好准备。这些协同变化是通过细胞内信号通路以及旁分泌和自分泌调节环路的激活来调节的。这篇综述将总结目前对 LH 触发的分子事件的了解，主要关注卵母细胞成熟所需的信号通路。
During the peri-ovulatory period, the gonadotropin LH triggers major changes in both the somatic and germ cell compartments of the ovarian follicle. The oocyte completes the meiotic cell cycle to become a fertilizable egg, and dramatic changes in gene expression and secretion take place in the somatic compartment of the follicle in preparation for follicular rupture and oocyte release. The concerted changes are regulated by activation of intracellular signaling pathways as well as paracrine and autocrine regulatory loops. This review will provide a summary of the current knowledge of the molecular events triggered by LH focusing mostly on the signaling pathways required for oocyte maturation.
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DOI：
10.1126/science.1171396
发表时间：
2009-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fan HY;Liu Z;Shimada M;Sterneck E;Johnson PF;Hedrick SM;Richards JS
通讯作者：
Richards JS
影响因子：
4.8
作者：
Carvalho, CRO;Carvalheira, JBC;Saad, MJA
通讯作者：
Saad, MJA
影响因子：
6.1
作者：
De la Fuente, R;O'Brien, MJ;Eppig, JJ
通讯作者：
Eppig, JJ
影响因子：
3.6
作者：
Cameron, MR;Foster, JS;Wimalasena, J
通讯作者：
Wimalasena, J
影响因子：
--
作者：
Andric, Nebojsa;Thomas, Mika;Ascoli, Mario
通讯作者：
Ascoli, Mario