Aging faster: worry and rumination in late life are associated with greater brain age.
Aging faster: worry and rumination in late life are associated with greater brain age.
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DOI：
10.1016/j.neurobiolaging.2021.01.009
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发表时间：
2021-05
影响因子：
4.2
通讯作者：
Andreescu C
中科院分区：
文献类型：
--
作者：
Karim HT;Ly M;Yu G;Krafty R;Tudorascu DL;Aizenstein HJ;Andreescu C
患有焦虑症的老年人大脑灰质体积较低-这是加速衰老的一个组成部分。我们之前已经验证了一个机器学习模型来预测大脑年龄，这是一个基于体素灰质图像的个体年龄估计。我们调查了大脑年龄与焦虑、抑郁、压力和情绪调节之间的关系。我们招募了78名参与者（≥ 50岁），沿着广泛的担忧严重程度。我们收集了成像数据并计算了逐体素的灰质图像，这些图像被输入到现有的机器学习模型中以估计大脑年龄。我们进行了多变量线性回归脑年龄和年龄，性别，种族，教育，担心，焦虑，抑郁，反刍，神经质，压力，重新评价，和抑制。我们发现，大脑年龄越大，年龄越大，男性越多，越担心，越沉思，抑制越低。男性，忧虑和沉思与晚年加速衰老有关，表达抑制可能具有保护作用。这些结果为负性重复思维的转诊断模型提供了证据，负性重复思维与认知衰退、淀粉样蛋白和tau蛋白相关。
Older adults with anxiety have lower gray matter brain volume – a component of accelerated aging. We have previously validated a machine learning model to predict brain age, an estimate of an individual’s age based on voxel-wise gray matter images. We investigated associations between brain age and anxiety, depression, stress, and emotion regulation. We recruited 78 participants (≥50yrs) along a wide range of worry severity. We collected imaging data and computed voxel-wise gray matter images, which was input into an existing machine learning model to estimate brain age. We conducted a multivariable linear regression between brain age and age, sex, race, education, worry, anxiety, depression, rumination, neuroticism, stress, reappraisal, and suppression. We found that greater brain age was significantly associated with greater age, male sex, greater worry, greater rumination, and lower suppression. Male sex, worry and rumination are associated with accelerated aging in late life and expressive suppression may have a protective effect. These results provide evidence for the transdiagnostic model of negative repetitive thoughts, which are associated with cognitive decline, amyloid, and tau.
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影响因子：
11.2
作者：
Cole, James H.;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
影响因子：
11.3
作者：
Andreescu C;Mennin D;Tudorascu D;Sheu LK;Walker S;Banihashemi L;Aizenstein H
通讯作者：
Aizenstein H
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
2.6
作者：
Giuliani, Nicole R.;Drabant, Emily M.;Gross, James J.
通讯作者：
Gross, James J.
影响因子：
2.8
作者：
Bagby, RM;Rector, NA;McBride, C
通讯作者：
McBride, C