Prediction of brain age suggests accelerated atrophy after traumatic brain injury.
Prediction of brain age suggests accelerated atrophy after traumatic brain injury.
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DOI：
10.1002/ana.24367
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发表时间：
2015-04
影响因子：
11.2
通讯作者：
Sharp, David J.
中科院分区：
文献类型：
--
作者：
Cole, James H.;Leech, Robert;Sharp, David J.
创伤性脑损伤（TBI）的长期影响可能与正常衰老过程中观察到的情况相似，这表明TBI可能会加速衰老进程。我们利用一种神经影像学模型对此进行研究，该模型可预测健康个体的大脑年龄，然后将其应用于TBI患者。我们确定了个体在实际年龄和预测的大脑结构“年龄”方面的差异，并测试TBI是否会导致进行性萎缩以及这与认知功能有何关系。
基于对灰质（GM）和白质（WM）的磁共振成像估计，利用机器学习在1537名健康个体中确定了一个正常衰老的预测模型。然后将这个衰老模型应用于对99名TBI患者和113名健康对照者进行测试以估计大脑年龄。
初始模型能准确预测健康个体的年龄（相关系数r = 0.92）。据估计，TBI患者的大脑“更老”，灰质的实际年龄和估计大脑年龄之间的平均预测年龄差异（PAD）为4.66年（±10.8），白质为5.97年（±11.22）。这种PAD可预测认知障碍，并且与TBI发生后的时间密切相关，这表明在慢性损伤后阶段脑组织损失不断增加。
据估计，TBI患者的大脑比他们的实际年龄更老。这种差异随着受伤时间的推移而增大，这表明TBI会加速脑萎缩的速度。这可能是TBI患者更容易患痴呆和其他与年龄相关疾病的一个重要因素，这促使进一步研究脑损伤和其他神经系统疾病类似衰老的影响。
The long-term effects of traumatic brain injury (TBI) can resemble observed in normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients. We define individuals' differences in chronological and predicted structural "brain age," and test whether TBI produces progressive atrophy and how this relates to cognitive function. A predictive model of normal ageing was defined using machine learning in 1,537 healthy individuals, based on magnetic resonance imaging–derived estimates of gray matter (GM) and white matter (WM). This ageing model was then applied to test 99 TBI patients and 113 healthy controls to estimate brain age. The initial model accurately predicted age in healthy individuals (r * 0.92). TBI brains were estimated to be "older," with a mean predicted age difference (PAD) between chronological and estimated brain age of 4.66 years (±10.8) for GM and 5.97 years (±11.22) for WM. This PAD predicted cognitive impairment and correlated strongly with the time since TBI, indicating that brain tissue loss increases throughout the chronic postinjury phase. TBI patients' brains were estimated to be older than their chronological age. This discrepancy increases with time since injury, suggesting that TBI accelerates the rate of brain atrophy. This may be an important factor in the increased susceptibility in TBI patients for dementia and other age-associated conditions, motivating further research into the age-like effects of brain injury and other neurological diseases.
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