Error monitoring dysfunction across the illness course of schizophrenia.
Error monitoring dysfunction across the illness course of schizophrenia.
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DOI：
10.1037/a0025487
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发表时间：
2012-05
影响因子：
4.6
通讯作者：
Mathalon DH
中科院分区：
文献类型：
--
作者：
Perez VB;Ford JM;Roach BJ;Woods SW;McGlashan TH;Srihari VH;Loewy RL;Vinogradov S;Mathalon DH
在慢性精神分裂症患者中已经报告了反应监测异常，但尚不清楚它们是否早于精神病发作，是否存在于疾病的早期阶段，或者是否是与疾病进展相关的晚期发展异常。反应同步事件相关电位（ERP）记录在一个图片-文字匹配任务产生错误相关负波（ERN），正确反应负波（CRN），错误阳性（Pe）从84精神分裂症患者（SZ），48名临床高危患者（PNS），和他们的年龄匹配的健康对照组（HC; n = 110和88，分别）。一个子样本的35个早期疾病精神分裂症患者（ESZ）进行了比较，93个年龄匹配的HC和ESTA患者（在统计学上消除正常老化的影响）。相对于HC，1）SZ、ESZ和ESN的ERN较小，2）SZ和ESZ的CRN较大，Pes较小。在SZ中，较长的病程与较大的CRN相关，但与ERN或Pe无关。ERN和ESZ没有不同的ERN或CRN，虽然Pe小于ESZ比CHR。这些结果表明，而ERN，CRN，和Pe异常存在于疾病的早期，只有ERN异常是明显的精神病发作前，只有CRN异常出现在病程中逐步恶化。负责反应监测的脑区可能在疾病早期和临床前驱症状期间受到损害。
Response monitoring abnormalities have been reported in chronic schizophrenia patients, but it is unknown whether they predate the onset of psychosis, are present in early stages of illness, or are late-developing abnormalities associated with illness progression. Response-synchronized event-related potentials (ERP) recorded during a picture-word matching task yielded error-related negativity (ERN), correct-response negativity (CRN), and error positivity (Pe) from 84 schizophrenia patients (SZ), 48 clinical high risk patients (CHR), and their age-matched healthy controls (HC; n = 110 and 88, respectively). A sub-sample of 35 early illness schizophrenia patients (ESZ) was compared to 93 age-matched HC and the CHR patients (after statistically removing the effects of normal aging). Relative to HC, 1) SZ, ESZ, and CHR had smaller ERNs, and 2) SZ and ESZ had larger CRNs and smaller Pes. Within the SZ, longer illness duration was associated with larger CRNs but was unrelated to ERN or Pe. CHR and ESZ did not differ on ERN or CRN, although Pe was smaller in ESZ than CHR. These results indicate that while ERN, CRN, and Pe abnormalities are present early in the illness, only the ERN abnormality is evident prior to psychosis onset, and only the CRN abnormality appears to worsen progressively over the illness course. Brain regions subserving response monitoring may be compromised early in the illness and possibly during its clinical prodrome.
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