The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.
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精神分裂症多基因风险评分和大麻使用模式对首发精神病跨诊断症状维度影响的连续性：来自EU-GEI研究的结果
DOI：
10.1038/s41398-021-01526-0
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发表时间：
2021-08-10
影响因子：
6.8
通讯作者：
EU-GEI collaborators
中科院分区：
文献类型：
--
作者：
Quattrone D;Reininghaus U;Richards AL;Tripoli G;Ferraro L;Quattrone A;Marino P;Rodriguez V;Spinazzola E;Gayer-Anderson C;Jongsma HE;Jones PB;La Cascia C;La Barbera D;Tarricone I;Bonora E;Tosato S;Lasalvia A;Szöke A;Arango C;Bernardo M;Bobes J;Del Ben CM;Menezes PR;Llorca PM;Santos JL;Sanjuán J;Arrojo M;Tortelli A;Velthorst E;Berendsen S;de Haan L;Rutten BPF;Lynskey MT;Freeman TP;Kirkbride JB;Sham PC;O'Donovan MC;Cardno AG;Vassos E;van Os J;Morgan C;Murray RM;Lewis CM;Di Forti M;EU-GEI collaborators
诊断分类不能完全反映精神病的异质性表达。使用EU-GEI研究的数据，我们评估了精神分裂症多基因风险评分（SZ-PRS）和大麻使用模式对精神病转诊断表达的影响。我们分析了首发精神病患者（FEP）和对照组，使用项目反应双因素模型生成精神病症状和经历的跨诊断维度。使用线性回归检验这些维度与SZ-PRS之间的关联，以及SZ-PRS和大麻使用对阳性精神病症状和经历维度的综合影响。我们发现SZ-PRS与(1)617例FEP患者的阴性（B = 0.18; 95%CI 0.03-0.33）和阳性（B = 0.19; 95%CI 0.03-0.35）症状维度之间存在相关性，无论其分类诊断如何；(2) 979名对照者的所有精神体验维度。我们没有观察到SZ-PRS与FEP的一般维度和情感维度之间的关联。每日和当前使用大麻与FEP （B = 0.31; 95%CI 0.11-0.52）和对照组（B = 0.26; 95%CI 0.06-0.46）的积极维度相关，高于SZ-PRS。我们提供的证据表明，精神分裂症和大麻使用的遗传倾向性映射到跨诊断症状维度，支持精神病维度表征的有效性和实用性。在我们的样本中，精神分裂症的遗传倾向与更严重的精神病表现相关，大麻使用赋予阳性症状的风险超出了遗传风险。我们的研究结果支持这样的假设，即一般人群的精神病经历与临床疾病具有相似的遗传基础。
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
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DOI：
10.1016/s2215-0366(19)30048-3
发表时间：
2019-05
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Di Forti M;Quattrone D;Freeman TP;Tripoli G;Gayer-Anderson C;Quigley H;Rodriguez V;Jongsma HE;Ferraro L;La Cascia C;La Barbera D;Tarricone I;Berardi D;Szöke A;Arango C;Tortelli A;Velthorst E;Bernardo M;Del-Ben CM;Menezes PR;Selten JP;Jones PB;Kirkbride JB;Rutten BP;de Haan L;Sham PC;van Os J;Lewis CM;Lynskey M;Morgan C;Murray RM;EU-GEI WP2 Group
通讯作者：
EU-GEI WP2 Group
影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
25.8
作者：
Allardyce J;Leonenko G;Hamshere M;Pardiñas AF;Forty L;Knott S;Gordon-Smith K;Porteous DJ;Haywood C;Di Florio A;Jones L;McIntosh AM;Owen MJ;Holmans P;Walters JTR;Craddock N;Jones I;O'Donovan MC;Escott-Price V
通讯作者：
Escott-Price V
影响因子：
10.5
作者：
Cardno, AG;Sham, PC;McGuffin, P
通讯作者：
McGuffin, P