The roles of fibroblast growth factors in the testicular development and tumor.
The roles of fibroblast growth factors in the testicular development and tumor.
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DOI：
10.1155/2013/489095
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发表时间：
2013
影响因子：
4.3
通讯作者：
Qu Y
中科院分区：
文献类型：
--
作者：
Jiang X;Skibba M;Zhang C;Tan Y;Xin Y;Qu Y
成纤维细胞生长因子（FGF）通常被称为激素因子，最近的研究表明，FGF在调节包括睾丸在内的几种生殖器官的生长和发育中具有关键作用。睾丸主要由生殖细胞、支持细胞和间质细胞组成，以发育和维持雄性表型和生殖。本文就睾丸的结构与功能、FGF在睾丸发育中的作用、FGF与睾丸肿瘤的关系及其调控机制作一综述。其中FGF-1、FGF-2、FGF-4、FGF-8、FGF-9、FGF-21共23个成员，本文对它们的功能进行了详细的描述。了解FGF的作用和机制是睾丸发育模型和睾丸疾病治疗的基础。因此，在最后一部分中，我们还讨论了FGF在睾丸肿瘤和糖尿病治疗中的应用前景。
Fibroblast growth factors (FGFs) are classically known as hormonal factors and recent studies have revealed that FGFs have a key role in regulating growth and development of several reproductive organs, including the testis. The testis is mainly consisted of germ cells, Sertoli cells and Leydig cells to develop and maintain the male phenotype and reproduction. This review summarizes the structure and fuctions of testis, the roles of FGFs on testicular development and potential involvement in testicular tumor and its regulatory mechanism. Among 23 members of FGFs, the FGF-1, FGF-2, FGF-4, FGF-8, FGF-9, and FGF-21 were involved and describe in details. Understanding the roles and mechanism of FGFs is the foundation to modeling testicular development and treatments in testicular disease. Therefore, in the last part, the potential therapy with FGFs for the testis of cancer and diabetes was also discussed.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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