Dopamine in motivational control: rewarding, aversive, and alerting.

Dopamine in motivational control: rewarding, aversive, and alerting.
复制标题

DOI:
10.1016/j.neuron.2010.11.022
复制
发表时间:
2010-12-09
期刊:
影响因子:
16.2
通讯作者:
Hikosaka, Okihide
Hikosaka, Okihide
中科院分区:
医学1区
文献类型:
--
作者:
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide

文献摘要

参考文献

被引文献

相似文献

中脑多巴胺神经元以其对奖励的强烈反应和在积极动机中的关键作用而闻名。然而,越来越清楚的是,多巴胺神经元也传递与显著但非奖励性体验相关的信号,如厌恶和警觉事件。在这里,我们回顾了最近的进展,了解多巴胺的奖励和非奖励功能。基于这些数据,我们提出多巴胺神经元有多种类型,它们与不同的大脑网络相连,在动机控制中扮演不同的角色。一些多巴胺神经元编码动机价值,支持大脑网络寻求,评估和价值学习。另一些编码动机的突出性,支持大脑网络的定向,认知和一般动机。这两种类型的多巴胺神经元都被一种警报信号所增强,这种警报信号参与了对潜在的重要感觉线索的快速检测。我们假设,这些多巴胺能通路的价值,显着性和警觉合作,以支持适应性行为。
Midbrain dopamine neurons are well known for their strong responses to rewards and their critical role in positive motivation. It has become increasingly clear, however, that dopamine neurons also transmit signals related to salient but non-rewarding experiences such as aversive and alerting events. Here we review recent advances in understanding the reward and non-reward functions of dopamine. Based on this data, we propose that dopamine neurons come in multiple types that are connected with distinct brain networks and have distinct roles in motivational control. Some dopamine neurons encode motivational value, supporting brain networks for seeking, evaluation, and value learning. Others encode motivational salience, supporting brain networks for orienting, cognition, and general motivation. Both types of dopamine neurons are augmented by an alerting signal involved in rapid detection of potentially important sensory cues. We hypothesize that these dopaminergic pathways for value, salience, and alerting cooperate to support adaptive behavior.
DOI: 10.1146/annurev-neuro-060909-152823
发表时间: 2010
影响因子: 13.9
作者:
Bisley JW;Goldberg ME
通讯作者: Goldberg ME
DOI: 10.1073/pnas.0910986107
发表时间: 2010-01-05
影响因子: 11.1
作者:
Birgner, Carolina;Nordenankar, Karin;Wallen-Mackenzie, Asa
通讯作者: Wallen-Mackenzie, Asa
DOI: 10.1016/j.neuron.2010.06.031
发表时间: 2010-08-12
期刊: NEURON
影响因子: 16.2
作者:
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
通讯作者: Hikosaka, Okihide
DOI: 10.1016/j.neuroscience.2009.03.023
发表时间: 2009-06-16
期刊: Neuroscience
影响因子: 3.3
作者:
通讯作者: --
在行动中构建学习。
DOI: 10.1016/j.bbr.2009.08.031
发表时间: 2010-01-20
影响因子: 2.7
作者:
Braun, Daniel A.;Mehring, Carsten;Wolpert, Daniel M.
通讯作者: Wolpert, Daniel M.