Dopamine in motivational control: rewarding, aversive, and alerting.
Dopamine in motivational control: rewarding, aversive, and alerting.
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DOI:
10.1016/j.neuron.2010.11.022
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发表时间:
2010-12-09
期刊:
影响因子:
16.2
通讯作者:
Hikosaka, Okihide
中科院分区:
文献类型:
--
作者:
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
Midbrain dopamine neurons are well known for their strong responses to rewards and their critical role in positive motivation. It has become increasingly clear, however, that dopamine neurons also transmit signals related to salient but non-rewarding experiences such as aversive and alerting events. Here we review recent advances in understanding the reward and non-reward functions of dopamine. Based on this data, we propose that dopamine neurons come in multiple types that are connected with distinct brain networks and have distinct roles in motivational control. Some dopamine neurons encode motivational value, supporting brain networks for seeking, evaluation, and value learning. Others encode motivational salience, supporting brain networks for orienting, cognition, and general motivation. Both types of dopamine neurons are augmented by an alerting signal involved in rapid detection of potentially important sensory cues. We hypothesize that these dopaminergic pathways for value, salience, and alerting cooperate to support adaptive behavior.
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影响因子:
13.9
作者:
Bisley JW;Goldberg ME
通讯作者:
Goldberg ME
DOI:
10.1073/pnas.0910986107
发表时间:
2010-01-05
影响因子:
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作者:
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通讯作者:
Wallen-Mackenzie, Asa
影响因子:
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作者:
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
通讯作者:
Hikosaka, Okihide
影响因子:
3.3
作者:
通讯作者:
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影响因子:
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作者:
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通讯作者:
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