ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer.
ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer.
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DOI：
10.1186/1471-2407-14-705
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发表时间：
2014-09-24
期刊：
影响因子：
3.8
通讯作者：
Luo WS
中科院分区：
文献类型：
--
作者：
Li XS;Xu Q;Fu XY;Luo WS
乙醛脱氢酶1家族成员A1(ALDH1A1)是一种肿瘤干细胞标记物，其表达与多种恶性肿瘤的预后相关。本研究旨在探讨ALDH1A1在胃癌中的表达及其与临床病理参数和预后的关系。应用免疫组织化学方法检测216例胃癌组织中ALDH1A1和基质金属肽酶9(MMP9)的表达。分析ALDH1A1和MMP9的表达与胃癌临床病理参数和预后的关系。ALDH1A1蛋白的表达与肿瘤的深度侵袭、淋巴结转移和分期显著相关(均P< <； <0.05)。单因素和多因素分析均显示ALDH1A1是总生存率(OS)和无复发生存率(RF)的独立预后因素(P <； 0.001)。此外，在按肿瘤大小、深度侵袭和淋巴结转移分组的患者中，ALDH1A1的过度表达与预后不良有关。此外，ALDH1A1与基质金属蛋白酶-9呈显著正相关(P <； 0.001)。ALDH1A1过表达的患者，肿瘤细胞表现出高侵袭性，OS较差，RFS较短。ALDH1A1在肿瘤侵袭性和预后中发挥重要作用，有望成为预测预后的靶点。
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a cancer stem cell marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of ALDH1A1 expression with clinicopathological parameters and prognosis in gastric cancer. ALDH1A1 and matrix metallopeptidase 9 (MMP-9) was evaluated by immunohistochemistry in 216 gastric carcinoma samples. The association between expression of ALDH1A1 and MMP-9, clinicopathological parameters, and prognosis of gastric cancer was examined. ALDH1A1 protein expression was significantly associated with depth invasion, lymph node metastasis and stage of disease (all P < 0.05). Both univariate and multivariate analyses revealed that ALDH1A1 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS) (both P < 0.001). Furthermore, ALDH1A1 overexpression was associated with poor prognosis in patients subgroups stratified by tumor size, depth invasion and lymph node metastasis. Moreover, ALDH1A1 was significantly correlated with MMP-9 among 216 gastric cancer tissues (P < 0.001). Patients who had ALDH1A1 overexpression, in which tumor cells displayed high invasiveness, had poor OS and shorter RFS. ALDH1A1 plays an important role in tumor aggressiveness and prognosis, and may act as a promising target for prognostic prediction.
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